Basic Information
Symbol
circFBXW7
RNA Class
circRNA
Alias
F-Box And WD Repeat Domain Containing 7
SEL-10
SEL10
FBX30
FBW7
FBXW6
CDC4
AGO
F-Box And WD Repeat Domain Containing 7, E3 Ubiquitin Protein Ligase
F-Box And WD-40 Domain Protein 7 (Archipelago Homolog, Drosophila)
F-Box/WD Repeat-Containing Protein 7
F-Box Protein FBX30
FLJ11071
HCdc4
HAgo
F-Box And WD-40 Domain-Containing Protein 7
Archipelago Homolog (Drosophila)
Homolog Of C Elegans Sel-10
F-Box Protein SEL-10
Archipelago Homolog
F-Box Protein FBW7
Archipelago
DEDHIL
FBXO30
FBW6
Location (GRCh37)
4:153243748-153456566
UCSC Genome Browser
Location (GRCh38)
4:152322596-152535414
Host gene
FBXW7
Host category
mRNA
Forensic tag(s)
Other applications
External database
Transcripts
| ID | Type | Location (GRCh37) | Location (GRCh38) | Length | GC content |
|---|---|---|---|---|---|
| hsa_FBXW7_0000500 | Exon-Exon | chr4:153244302-153245335 | chr4:152323150-152324183 | None nt | - |
| hsa_FBXW7_0001300 | Exon-Exon | chr4:153249360-153259088 | chr4:152328208-152337936 | 692 nt | 0.4176 |
| hsa_FBXW7_0001400 | Exon-Exon | chr4:153249360-153268223 | chr4:152328208-152347071 | 834 nt | 0.4341 |
| hsa_FBXW7_0001700 | Exon-Exon | chr4:153250824-153259088 | chr4:152329672-152337936 | 510 nt | 0.4176 |
| hsa_FBXW7_0001800 | Exon-Exon | chr4:153250824-153271276 | chr4:152329672-152350124 | 735 nt | 0.4340 |
| hsa_FBXW7_0002100 | Exon-Exon | chr4:153250824-153333681 | chr4:152329672-152412529 | 1962 nt | 0.3863 |
| hsa_FBXW7_0002200 | Exon-Exon | chr4:153251884-153259088 | chr4:152330732-152337936 | 396 nt | 0.4217 |
| hsa_FBXW7_0002800 | Exon-Exon | chr4:153253748-153259088 | chr4:152332596-152337936 | 259 nt | 0.4324 |
| hsa_FBXW7_0003900 | Exon-Exon | chr4:153268082-153271276 | chr4:152346930-152350124 | 225 nt | 0.4711 |
| hsa_chr4_0190500 | Intergenic-Intergenic | chr4:153272457-153272582 | chr4:152351305-152351430 | 126 nt | 0.3968 |
Showing 1 to 10 of 163 entries
Forensic Context
A study in human brain cancer demonstrated that the circFBXW7 functions as a tumor suppressor, where its expression inhibits cell progression, migration, and tumor formation [Di Agostino et al. DOI:10.3389/fcell.2020.00389]. Further research confirmed its coding potential, showing the translated peptide FBXW7-185aa reduces the half-life of c-Myc and inhibits cell cycle progression [Sema Misir et al. DOI:10.1038/s41418-022-00948-7]. The peptide FBXW7-185aa, which originates from the circFBXW7, inhibits cell cycle progression [Misir et al. DOI:10.1038/s41418-022-00948-7].