Basic Information

Symbol
circFBXW7
RNA Class
circRNA
Alias
F-Box And WD Repeat Domain Containing 7 SEL-10 SEL10 FBX30 FBW7 FBXW6 CDC4 AGO F-Box And WD Repeat Domain Containing 7, E3 Ubiquitin Protein Ligase F-Box And WD-40 Domain Protein 7 (Archipelago Homolog, Drosophila) F-Box/WD Repeat-Containing Protein 7 F-Box Protein FBX30 FLJ11071 HCdc4 HAgo F-Box And WD-40 Domain-Containing Protein 7 Archipelago Homolog (Drosophila) Homolog Of C Elegans Sel-10 F-Box Protein SEL-10 Archipelago Homolog F-Box Protein FBW7 Archipelago DEDHIL FBXO30 FBW6
Location (GRCh37)
4:153243748-153456566 UCSC Genome Browser
Location (GRCh38)
4:152322596-152535414
UCSC Genome Browser Search in Marker Scope
Host gene
FBXW7
Host category
mRNA
Forensic tag(s)
Other applications
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_FBXW7_0008500 Exon-Intron chr4:153332455-153372928 chr4:152411303-152451776 126 nt 0.4524
hsa_FBXW7_0007300 Exon-Intron chr4:153332455-153372932 chr4:152411303-152451780 250 nt 0.3960
hsa_FBXW7_0007400 Exon-Intron chr4:153332455-153393050 chr4:152411303-152471898 250 nt 0.3880
hsa_FBXW7_0008600 Exon-Intron chr4:153332455-153396997 chr4:152411303-152475845 188 nt 0.3777
hsa_FBXW7_0008700 Exon-Intron chr4:153332455-153403586 chr4:152411303-152482434 65 nt 0.3385
hsa_FBXW7_0007500 Exon-Intron chr4:153332455-153429214 chr4:152411303-152508062 250 nt 0.3960
hsa_FBXW7_0007600 Exon-Intron chr4:153332455-153445487 chr4:152411303-152524335 250 nt 0.3520
hsa_FBXW7_0008900 Exon-Exon chr4:153332698-153333667 chr4:152411546-152412515 36 nt 0.5000
hsa_chr4_0190800 Intergenic-Intergenic chr4:153332760-153456355 chr4:152411608-152535203 485 nt 0.5216
hsa_FBXW7_0009000 Exon-Exon chr4:153332848-153332985 chr4:152411696-152411833 138 nt 0.4928
Showing 91 to 100 of 163 entries
Forensic Context

A study in human brain cancer demonstrated that the circFBXW7 functions as a tumor suppressor, where its expression inhibits cell progression, migration, and tumor formation [Di Agostino et al. DOI:10.3389/fcell.2020.00389]. Further research confirmed its coding potential, showing the translated peptide FBXW7-185aa reduces the half-life of c-Myc and inhibits cell cycle progression [Sema Misir et al. DOI:10.1038/s41418-022-00948-7]. The peptide FBXW7-185aa, which originates from the circFBXW7, inhibits cell cycle progression [Misir et al. DOI:10.1038/s41418-022-00948-7].