Basic Information

Symbol
circFBXW7
RNA Class
circRNA
Alias
F-Box And WD Repeat Domain Containing 7 SEL-10 SEL10 FBX30 FBW7 FBXW6 CDC4 AGO F-Box And WD Repeat Domain Containing 7, E3 Ubiquitin Protein Ligase F-Box And WD-40 Domain Protein 7 (Archipelago Homolog, Drosophila) F-Box/WD Repeat-Containing Protein 7 F-Box Protein FBX30 FLJ11071 HCdc4 HAgo F-Box And WD-40 Domain-Containing Protein 7 Archipelago Homolog (Drosophila) Homolog Of C Elegans Sel-10 F-Box Protein SEL-10 Archipelago Homolog F-Box Protein FBW7 Archipelago DEDHIL FBXO30 FBW6
Location (GRCh37)
4:153243748-153456566 UCSC Genome Browser
Location (GRCh38)
4:152322596-152535414
UCSC Genome Browser Search in Marker Scope
Host gene
FBXW7
Host category
mRNA
Forensic tag(s)
Other applications
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_chr4_0190900 Intergenic-Intergenic chr4:153332889-153456566 chr4:152411737-152535414 567 nt 0.6032
hsa_chr4_0191000 Intergenic-Intergenic chr4:153333358-153333642 chr4:152412206-152412490 285 nt 0.2842
hsa_FBXW7_0009100 Intron-Intron chr4:153339867-153373739 chr4:152418715-152452587 250 nt 0.2600
hsa_FBXW7_0009200 Intron-Intron chr4:153340821-153341119 chr4:152419669-152419967 299 nt 0.3478
hsa_FBXW7_0009300 Intron-Intron chr4:153340982-153362411 chr4:152419830-152441259 250 nt 0.3040
hsa_FBXW7_0009400 Intron-Intron chr4:153340982-153391140 chr4:152419830-152469988 186 nt 0.3710
hsa_FBXW7_0009500 Intron-Intron chr4:153348322-153348711 chr4:152427170-152427559 204 nt 0.3725
hsa_FBXW7_0009600 Intron-Intron chr4:153348557-153391140 chr4:152427405-152469988 203 nt 0.3793
hsa_FBXW7_0009700 Intron-Intron chr4:153348557-153403825 chr4:152427405-152482673 155 nt 0.3871
hsa_FBXW7_0009800 Intron-Intron chr4:153350265-153434123 chr4:152429113-152512971 250 nt 0.4240
Showing 101 to 110 of 163 entries
Forensic Context

A study in human brain cancer demonstrated that the circFBXW7 functions as a tumor suppressor, where its expression inhibits cell progression, migration, and tumor formation [Di Agostino et al. DOI:10.3389/fcell.2020.00389]. Further research confirmed its coding potential, showing the translated peptide FBXW7-185aa reduces the half-life of c-Myc and inhibits cell cycle progression [Sema Misir et al. DOI:10.1038/s41418-022-00948-7]. The peptide FBXW7-185aa, which originates from the circFBXW7, inhibits cell cycle progression [Misir et al. DOI:10.1038/s41418-022-00948-7].