Basic Information

Symbol
circFBXW7
RNA Class
circRNA
Alias
F-Box And WD Repeat Domain Containing 7 SEL-10 SEL10 FBX30 FBW7 FBXW6 CDC4 AGO F-Box And WD Repeat Domain Containing 7, E3 Ubiquitin Protein Ligase F-Box And WD-40 Domain Protein 7 (Archipelago Homolog, Drosophila) F-Box/WD Repeat-Containing Protein 7 F-Box Protein FBX30 FLJ11071 HCdc4 HAgo F-Box And WD-40 Domain-Containing Protein 7 Archipelago Homolog (Drosophila) Homolog Of C Elegans Sel-10 F-Box Protein SEL-10 Archipelago Homolog F-Box Protein FBW7 Archipelago DEDHIL FBXO30 FBW6
Location (GRCh37)
4:153243748-153456566 UCSC Genome Browser
Location (GRCh38)
4:152322596-152535414
UCSC Genome Browser Search in Marker Scope
Host gene
FBXW7
Host category
mRNA
Forensic tag(s)
Other applications
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_FBXW7_0009900 Intron-Intron chr4:153361513-153361870 chr4:152440361-152440718 358 nt 0.2989
hsa_FBXW7_0010000 Intron-Intron chr4:153361708-153377165 chr4:152440556-152456013 205 nt 0.3317
hsa_FBXW7_0010100 Intron-Intron chr4:153361708-153391140 chr4:152440556-152469988 113 nt 0.3009
hsa_FBXW7_0010200 Intron-Intron chr4:153361708-153396997 chr4:152440556-152475845 203 nt 0.3202
hsa_FBXW7_0010300 Intron-Intron chr4:153362249-153403825 chr4:152441097-152482673 250 nt 0.2920
hsa_FBXW7_0010400 Intron-Intron chr4:153363093-153363520 chr4:152441941-152442368 428 nt 0.3598
hsa_FBXW7_0010500 Intron-Intron chr4:153363155-153363520 chr4:152442003-152442368 366 nt 0.3607
hsa_FBXW7_0010600 Intron-Intron chr4:153363350-153363614 chr4:152442198-152442462 265 nt 0.3925
hsa_chr4_0191100 Intergenic-Intergenic chr4:153363808-153364095 chr4:152442656-152442943 288 nt 0.3403
hsa_FBXW7_0010700 Intron-Intron chr4:153369604-153377165 chr4:152448452-152456013 250 nt 0.3440
Showing 111 to 120 of 163 entries
Forensic Context

A study in human brain cancer demonstrated that the circFBXW7 functions as a tumor suppressor, where its expression inhibits cell progression, migration, and tumor formation [Di Agostino et al. DOI:10.3389/fcell.2020.00389]. Further research confirmed its coding potential, showing the translated peptide FBXW7-185aa reduces the half-life of c-Myc and inhibits cell cycle progression [Sema Misir et al. DOI:10.1038/s41418-022-00948-7]. The peptide FBXW7-185aa, which originates from the circFBXW7, inhibits cell cycle progression [Misir et al. DOI:10.1038/s41418-022-00948-7].