Basic Information

Symbol
circFBXW7
RNA Class
circRNA
Alias
F-Box And WD Repeat Domain Containing 7 SEL-10 SEL10 FBX30 FBW7 FBXW6 CDC4 AGO F-Box And WD Repeat Domain Containing 7, E3 Ubiquitin Protein Ligase F-Box And WD-40 Domain Protein 7 (Archipelago Homolog, Drosophila) F-Box/WD Repeat-Containing Protein 7 F-Box Protein FBX30 FLJ11071 HCdc4 HAgo F-Box And WD-40 Domain-Containing Protein 7 Archipelago Homolog (Drosophila) Homolog Of C Elegans Sel-10 F-Box Protein SEL-10 Archipelago Homolog F-Box Protein FBW7 Archipelago DEDHIL FBXO30 FBW6
Location (GRCh37)
4:153243748-153456566 UCSC Genome Browser
Location (GRCh38)
4:152322596-152535414
UCSC Genome Browser Search in Marker Scope
Host gene
FBXW7
Host category
mRNA
Forensic tag(s)
Other applications
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_FBXW7_0010800 Intron-Intron chr4:153369604-153396997 chr4:152448452-152475845 250 nt 0.3440
hsa_FBXW7_0010900 Intron-Intron chr4:153369604-153403825 chr4:152448452-152482673 250 nt 0.3400
hsa_chr4_0191200 Intergenic-Intergenic chr4:153370527-153370734 chr4:152449375-152449582 208 nt 0.3221
hsa_FBXW7_0011000 Intron-Intron chr4:153371415-153377165 chr4:152450263-152456013 250 nt 0.3240
hsa_FBXW7_0011100 Intron-Intron chr4:153371415-153391140 chr4:152450263-152469988 241 nt 0.3402
hsa_FBXW7_0011200 Intron-Intron chr4:153371415-153403825 chr4:152450263-152482673 118 nt 0.4661
hsa_FBXW7_0011300 Intron-Intron chr4:153372034-153391140 chr4:152450882-152469988 235 nt 0.3447
hsa_FBXW7_0011400 Intron-Intron chr4:153372034-153403825 chr4:152450882-152482673 304 nt 0.3684
hsa_FBXW7_0011500 Intron-Intron chr4:153373574-153377165 chr4:152452422-152456013 326 nt 0.3282
hsa_FBXW7_0011600 Intron-Intron chr4:153374033-153396997 chr4:152452881-152475845 138 nt 0.3478
Showing 121 to 130 of 163 entries
Forensic Context

A study in human brain cancer demonstrated that the circFBXW7 functions as a tumor suppressor, where its expression inhibits cell progression, migration, and tumor formation [Di Agostino et al. DOI:10.3389/fcell.2020.00389]. Further research confirmed its coding potential, showing the translated peptide FBXW7-185aa reduces the half-life of c-Myc and inhibits cell cycle progression [Sema Misir et al. DOI:10.1038/s41418-022-00948-7]. The peptide FBXW7-185aa, which originates from the circFBXW7, inhibits cell cycle progression [Misir et al. DOI:10.1038/s41418-022-00948-7].