Basic Information

Symbol
circFBXW7
RNA Class
circRNA
Alias
F-Box And WD Repeat Domain Containing 7 SEL-10 SEL10 FBX30 FBW7 FBXW6 CDC4 AGO F-Box And WD Repeat Domain Containing 7, E3 Ubiquitin Protein Ligase F-Box And WD-40 Domain Protein 7 (Archipelago Homolog, Drosophila) F-Box/WD Repeat-Containing Protein 7 F-Box Protein FBX30 FLJ11071 HCdc4 HAgo F-Box And WD-40 Domain-Containing Protein 7 Archipelago Homolog (Drosophila) Homolog Of C Elegans Sel-10 F-Box Protein SEL-10 Archipelago Homolog F-Box Protein FBW7 Archipelago DEDHIL FBXO30 FBW6
Location (GRCh37)
4:153243748-153456566 UCSC Genome Browser
Location (GRCh38)
4:152322596-152535414
UCSC Genome Browser Search in Marker Scope
Host gene
FBXW7
Host category
mRNA
Forensic tag(s)
Other applications
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_FBXW7_0011700 Intron-Intron chr4:153374259-153379281 chr4:152453107-152458129 250 nt 0.4200
hsa_chr4_0191300 Intergenic-Intergenic chr4:153376168-153376451 chr4:152455016-152455299 284 nt 0.2676
hsa_FBXW7_0011800 Intron-Intron chr4:153377026-153403825 chr4:152455874-152482673 250 nt 0.2840
hsa_chr4_0191400 Intergenic-Intergenic chr4:153379456-153380799 chr4:152458304-152459647 1344 nt 0.3981
hsa_chr4_0191500 Intergenic-Intergenic chr4:153382883-153383050 chr4:152461731-152461898 168 nt 0.3869
hsa_FBXW7_0011900 Intron-Intron chr4:153382994-153383232 chr4:152461842-152462080 239 nt 0.3515
hsa_FBXW7_0012000 Intron-Intron chr4:153383510-153403825 chr4:152462358-152482673 250 nt 0.3280
hsa_FBXW7_0012100 Intron-Intron chr4:153383653-153391140 chr4:152462501-152469988 118 nt 0.4068
hsa_FBXW7_0012200 Intron-Intron chr4:153383653-153398932 chr4:152462501-152477780 118 nt 0.4068
hsa_FBXW7_0012300 Intron-Intron chr4:153388371-153388519 chr4:152467219-152467367 149 nt 0.4698
Showing 131 to 140 of 163 entries
Forensic Context

A study in human brain cancer demonstrated that the circFBXW7 functions as a tumor suppressor, where its expression inhibits cell progression, migration, and tumor formation [Di Agostino et al. DOI:10.3389/fcell.2020.00389]. Further research confirmed its coding potential, showing the translated peptide FBXW7-185aa reduces the half-life of c-Myc and inhibits cell cycle progression [Sema Misir et al. DOI:10.1038/s41418-022-00948-7]. The peptide FBXW7-185aa, which originates from the circFBXW7, inhibits cell cycle progression [Misir et al. DOI:10.1038/s41418-022-00948-7].