Basic Information

Symbol
circFBXW7
RNA Class
circRNA
Alias
F-Box And WD Repeat Domain Containing 7 SEL-10 SEL10 FBX30 FBW7 FBXW6 CDC4 AGO F-Box And WD Repeat Domain Containing 7, E3 Ubiquitin Protein Ligase F-Box And WD-40 Domain Protein 7 (Archipelago Homolog, Drosophila) F-Box/WD Repeat-Containing Protein 7 F-Box Protein FBX30 FLJ11071 HCdc4 HAgo F-Box And WD-40 Domain-Containing Protein 7 Archipelago Homolog (Drosophila) Homolog Of C Elegans Sel-10 F-Box Protein SEL-10 Archipelago Homolog F-Box Protein FBW7 Archipelago DEDHIL FBXO30 FBW6
Location (GRCh37)
4:153243748-153456566 UCSC Genome Browser
Location (GRCh38)
4:152322596-152535414
UCSC Genome Browser Search in Marker Scope
Host gene
FBXW7
Host category
mRNA
Forensic tag(s)
Other applications
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_chr4_0191600 Intergenic-Intergenic chr4:153390702-153395562 chr4:152469550-152474410 250 nt 0.2440
hsa_FBXW7_0012700 Intron-Intron chr4:153391093-153396997 chr4:152469941-152475845 138 nt 0.3478
hsa_FBXW7_0012800 Intron-Intron chr4:153391093-153398932 chr4:152469941-152477780 344 nt 0.3372
hsa_FBXW7_0012900 Intron-Intron chr4:153391093-153398965 chr4:152469941-152477813 279 nt 0.3548
hsa_FBXW7_0012500 Intron-Intron chr4:153391093-153398995 chr4:152469941-152477843 250 nt 0.2360
hsa_FBXW7_0013000 Intron-Intron chr4:153391093-153408821 chr4:152469941-152487669 139 nt 0.3597
hsa_FBXW7_0013100 Intron-Intron chr4:153391093-153416420 chr4:152469941-152495268 48 nt 0.3542
hsa_FBXW7_0012600 Intron-Intron chr4:153391093-153429214 chr4:152469941-152508062 250 nt 0.3360
hsa_FBXW7_0013200 Intron-Intron chr4:153392927-153396997 chr4:152471775-152475845 250 nt 0.3640
hsa_FBXW7_0013300 Intron-Intron chr4:153394350-153394727 chr4:152473198-152473575 378 nt 0.3704
Showing 141 to 150 of 163 entries
Forensic Context

A study in human brain cancer demonstrated that the circFBXW7 functions as a tumor suppressor, where its expression inhibits cell progression, migration, and tumor formation [Di Agostino et al. DOI:10.3389/fcell.2020.00389]. Further research confirmed its coding potential, showing the translated peptide FBXW7-185aa reduces the half-life of c-Myc and inhibits cell cycle progression [Sema Misir et al. DOI:10.1038/s41418-022-00948-7]. The peptide FBXW7-185aa, which originates from the circFBXW7, inhibits cell cycle progression [Misir et al. DOI:10.1038/s41418-022-00948-7].