Basic Information

Symbol
circFBXW7
RNA Class
circRNA
Alias
F-Box And WD Repeat Domain Containing 7 SEL-10 SEL10 FBX30 FBW7 FBXW6 CDC4 AGO F-Box And WD Repeat Domain Containing 7, E3 Ubiquitin Protein Ligase F-Box And WD-40 Domain Protein 7 (Archipelago Homolog, Drosophila) F-Box/WD Repeat-Containing Protein 7 F-Box Protein FBX30 FLJ11071 HCdc4 HAgo F-Box And WD-40 Domain-Containing Protein 7 Archipelago Homolog (Drosophila) Homolog Of C Elegans Sel-10 F-Box Protein SEL-10 Archipelago Homolog F-Box Protein FBW7 Archipelago DEDHIL FBXO30 FBW6
Location (GRCh37)
4:153243748-153456566 UCSC Genome Browser
Location (GRCh38)
4:152322596-152535414
UCSC Genome Browser Search in Marker Scope
Host gene
FBXW7
Host category
mRNA
Forensic tag(s)
Other applications
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_FBXW7_0013400 Intron-Intron chr4:153396908-153403825 chr4:152475756-152482673 250 nt 0.2720
hsa_FBXW7_0013500 Intron-Intron chr4:153396908-153452002 chr4:152475756-152530850 250 nt 0.3240
hsa_FBXW7_0013600 Intron-Intron chr4:153403095-153403825 chr4:152481943-152482673 731 nt 0.3529
hsa_FBXW7_0013700 Intron-Intron chr4:153403522-153403825 chr4:152482370-152482673 304 nt 0.3684
hsa_FBXW7_0013800 Intron-Exon chr4:153403522-153456185 chr4:152482370-152535033 397 nt 0.4257
hsa_FBXW7_0013900 Intron-Intron chr4:153406037-153439250 chr4:152484885-152518098 250 nt 0.3920
hsa_chr4_0191700 Intergenic-Intergenic chr4:153410568-153411261 chr4:152489416-152490109 694 nt 0.3386
hsa_FBXW7_0014000 Intron-Intron chr4:153412245-153412385 chr4:152491093-152491233 141 nt 0.3262
hsa_chr4_0191800 Intergenic-Intergenic chr4:153416835-153417232 chr4:152495683-152496080 398 nt 0.4196
hsa_chr4_0191900 Intergenic-Intergenic chr4:153420246-153423163 chr4:152499094-152502011 2918 nt 0.3687
Showing 151 to 160 of 163 entries
Forensic Context

A study in human brain cancer demonstrated that the circFBXW7 functions as a tumor suppressor, where its expression inhibits cell progression, migration, and tumor formation [Di Agostino et al. DOI:10.3389/fcell.2020.00389]. Further research confirmed its coding potential, showing the translated peptide FBXW7-185aa reduces the half-life of c-Myc and inhibits cell cycle progression [Sema Misir et al. DOI:10.1038/s41418-022-00948-7]. The peptide FBXW7-185aa, which originates from the circFBXW7, inhibits cell cycle progression [Misir et al. DOI:10.1038/s41418-022-00948-7].