Basic Information
Symbol
circFBXW7
RNA Class
circRNA
Alias
F-Box And WD Repeat Domain Containing 7
SEL-10
SEL10
FBX30
FBW7
FBXW6
CDC4
AGO
F-Box And WD Repeat Domain Containing 7, E3 Ubiquitin Protein Ligase
F-Box And WD-40 Domain Protein 7 (Archipelago Homolog, Drosophila)
F-Box/WD Repeat-Containing Protein 7
F-Box Protein FBX30
FLJ11071
HCdc4
HAgo
F-Box And WD-40 Domain-Containing Protein 7
Archipelago Homolog (Drosophila)
Homolog Of C Elegans Sel-10
F-Box Protein SEL-10
Archipelago Homolog
F-Box Protein FBW7
Archipelago
DEDHIL
FBXO30
FBW6
Location (GRCh37)
4:153243748-153456566
UCSC Genome Browser
Location (GRCh38)
4:152322596-152535414
Host gene
FBXW7
Host category
mRNA
Forensic tag(s)
Other applications
External database
Transcripts
| ID | Type | Location (GRCh37) | Location (GRCh38) | Length | GC content |
|---|---|---|---|---|---|
| hsa_FBXW7_0014100 | Intron-Intron | chr4:153428132-153429597 | chr4:152506980-152508445 | 1466 nt | 0.3820 |
| hsa_FBXW7_0014200 | Intron-Intron | chr4:153452052-153453767 | chr4:152530900-152532615 | 1716 nt | 0.3636 |
| hsa_FBXW7_0014500 | Exon-Exon | chr4:153456279-153456479 | chr4:152535127-152535327 | 201 nt | 0.6617 |
Showing 161 to 163 of 163 entries
Forensic Context
A study in human brain cancer demonstrated that the circFBXW7 functions as a tumor suppressor, where its expression inhibits cell progression, migration, and tumor formation [Di Agostino et al. DOI:10.3389/fcell.2020.00389]. Further research confirmed its coding potential, showing the translated peptide FBXW7-185aa reduces the half-life of c-Myc and inhibits cell cycle progression [Sema Misir et al. DOI:10.1038/s41418-022-00948-7]. The peptide FBXW7-185aa, which originates from the circFBXW7, inhibits cell cycle progression [Misir et al. DOI:10.1038/s41418-022-00948-7].