Basic Information

Symbol
circFBXW7
RNA Class
circRNA
Alias
F-Box And WD Repeat Domain Containing 7 SEL-10 SEL10 FBX30 FBW7 FBXW6 CDC4 AGO F-Box And WD Repeat Domain Containing 7, E3 Ubiquitin Protein Ligase F-Box And WD-40 Domain Protein 7 (Archipelago Homolog, Drosophila) F-Box/WD Repeat-Containing Protein 7 F-Box Protein FBX30 FLJ11071 HCdc4 HAgo F-Box And WD-40 Domain-Containing Protein 7 Archipelago Homolog (Drosophila) Homolog Of C Elegans Sel-10 F-Box Protein SEL-10 Archipelago Homolog F-Box Protein FBW7 Archipelago DEDHIL FBXO30 FBW6
Location (GRCh37)
4:153243748-153456566 UCSC Genome Browser
Location (GRCh38)
4:152322596-152535414
UCSC Genome Browser Search in Marker Scope
Host gene
FBXW7
Host category
mRNA
Forensic tag(s)
Other applications
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_FBXW7_0007900 Exon-Exon chr4:153332455-153333681 chr4:152411303-152412529 1227 nt 0.3578
hsa_FBXW7_0006900 Exon-Intron chr4:153332455-153391140 chr4:152411303-152469988 250 nt 0.2920
hsa_FBXW7_0007000 Exon-Intron chr4:153332455-153403825 chr4:152411303-152482673 250 nt 0.3080
hsa_FBXW7_0008800 Exon-Exon chr4:153332455-153456185 chr4:152411303-152535033 663 nt 0.4766
hsa_FBXW7_0007100 Exon-Exon chr4:153332455-153456393 chr4:152411303-152535241 871 nt 0.5086
hsa_FBXW7_0012400 Intron-Intron chr4:153391093-153403825 chr4:152469941-152482673 250 nt 0.2480
hsa_FBXW7_0014300 Exon-Exon chr4:153456093-153456185 chr4:152534941-152535033 93 nt 0.6129
hsa_FBXW7_0014400 Exon-Exon chr4:153456093-153456393 chr4:152534941-152535241 301 nt 0.6113
hsa_RP11-461L13.2_0000100 Intergenic-Exon-Intergenic chr4:153253833-153268174 chr4:152332681-152347022 132 nt 0.5076
hsa_FBXW7_0000200 Exon-Exon chr4:153243748-153247383 chr4:152322596-152326231 991 nt 0.4369
Showing 11 to 20 of 163 entries
Forensic Context

A study in human brain cancer demonstrated that the circFBXW7 functions as a tumor suppressor, where its expression inhibits cell progression, migration, and tumor formation [Di Agostino et al. DOI:10.3389/fcell.2020.00389]. Further research confirmed its coding potential, showing the translated peptide FBXW7-185aa reduces the half-life of c-Myc and inhibits cell cycle progression [Sema Misir et al. DOI:10.1038/s41418-022-00948-7]. The peptide FBXW7-185aa, which originates from the circFBXW7, inhibits cell cycle progression [Misir et al. DOI:10.1038/s41418-022-00948-7].