Basic Information
Symbol
circFBXW7
RNA Class
circRNA
Alias
F-Box And WD Repeat Domain Containing 7
SEL-10
SEL10
FBX30
FBW7
FBXW6
CDC4
AGO
F-Box And WD Repeat Domain Containing 7, E3 Ubiquitin Protein Ligase
F-Box And WD-40 Domain Protein 7 (Archipelago Homolog, Drosophila)
F-Box/WD Repeat-Containing Protein 7
F-Box Protein FBX30
FLJ11071
HCdc4
HAgo
F-Box And WD-40 Domain-Containing Protein 7
Archipelago Homolog (Drosophila)
Homolog Of C Elegans Sel-10
F-Box Protein SEL-10
Archipelago Homolog
F-Box Protein FBW7
Archipelago
DEDHIL
FBXO30
FBW6
Location (GRCh37)
4:153243748-153456566
UCSC Genome Browser
Location (GRCh38)
4:152322596-152535414
Host gene
FBXW7
Host category
mRNA
Forensic tag(s)
Other applications
External database
Transcripts
| ID | Type | Location (GRCh37) | Location (GRCh38) | Length | GC content |
|---|---|---|---|---|---|
| hsa_FBXW7_0000300 | Exon-Exon | chr4:153243748-153259088 | chr4:152322596-152337936 | 1683 nt | 0.4290 |
| hsa_FBXW7_0000400 | Exon-Exon | chr4:153243748-153271276 | chr4:152322596-152350124 | 484 nt | 0.4504 |
| hsa_chr4_0190200 | Intergenic-Intergenic | chr4:153244127-153244273 | chr4:152322975-152323121 | 147 nt | 0.4490 |
| hsa_FBXW7_0000600 | Exon-Exon | chr4:153245336-153250937 | chr4:152324184-152329785 | 733 nt | 0.4243 |
| hsa_FBXW7_0000700 | Exon-Exon | chr4:153245336-153259088 | chr4:152324184-152337936 | 346 nt | 0.4075 |
| hsa_FBXW7_0000800 | Exon-Exon | chr4:153245501-153247229 | chr4:152324349-152326077 | 118 nt | 0.4407 |
| hsa_FBXW7_0000900 | Exon-Exon | chr4:153247158-153259088 | chr4:152326006-152337936 | 918 nt | 0.4259 |
| hsa_FBXW7_0001000 | Exon-Exon | chr4:153247158-153333681 | chr4:152326006-152412529 | 50 nt | 0.4600 |
| hsa_FBXW7_0001100 | Intron-Intron | chr4:153247408-153249359 | chr4:152326256-152328207 | 1952 nt | 0.3345 |
| hsa_FBXW7_0001200 | Intron-Intron | chr4:153247413-153249359 | chr4:152326261-152328207 | 1947 nt | 0.3349 |
Showing 21 to 30 of 163 entries
Forensic Context
A study in human brain cancer demonstrated that the circFBXW7 functions as a tumor suppressor, where its expression inhibits cell progression, migration, and tumor formation [Di Agostino et al. DOI:10.3389/fcell.2020.00389]. Further research confirmed its coding potential, showing the translated peptide FBXW7-185aa reduces the half-life of c-Myc and inhibits cell cycle progression [Sema Misir et al. DOI:10.1038/s41418-022-00948-7]. The peptide FBXW7-185aa, which originates from the circFBXW7, inhibits cell cycle progression [Misir et al. DOI:10.1038/s41418-022-00948-7].