Basic Information

Symbol
circFBXW7
RNA Class
circRNA
Alias
F-Box And WD Repeat Domain Containing 7 SEL-10 SEL10 FBX30 FBW7 FBXW6 CDC4 AGO F-Box And WD Repeat Domain Containing 7, E3 Ubiquitin Protein Ligase F-Box And WD-40 Domain Protein 7 (Archipelago Homolog, Drosophila) F-Box/WD Repeat-Containing Protein 7 F-Box Protein FBX30 FLJ11071 HCdc4 HAgo F-Box And WD-40 Domain-Containing Protein 7 Archipelago Homolog (Drosophila) Homolog Of C Elegans Sel-10 F-Box Protein SEL-10 Archipelago Homolog F-Box Protein FBW7 Archipelago DEDHIL FBXO30 FBW6
Location (GRCh37)
4:153243748-153456566 UCSC Genome Browser
Location (GRCh38)
4:152322596-152535414
UCSC Genome Browser Search in Marker Scope
Host gene
FBXW7
Host category
mRNA
Forensic tag(s)
Other applications
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_FBXW7_0001500 Exon-Exon chr4:153249360-153252020 chr4:152328208-152330868 257 nt 0.3969
hsa_FBXW7_0001600 Exon-Exon chr4:153249360-153271276 chr4:152328208-152350124 83 nt 0.3976
hsa_FBXW7_0001900 Exon-Exon chr4:153250824-153253871 chr4:152329672-152332719 375 nt 0.4240
hsa_FBXW7_0002000 Exon-Exon chr4:153250824-153268223 chr4:152329672-152347071 251 nt 0.4024
hsa_FBXW7_0002300 Exon-Exon chr4:153251884-153253871 chr4:152330732-152332719 261 nt 0.4330
hsa_FBXW7_0002400 Exon-Exon chr4:153251884-153268223 chr4:152330732-152347071 538 nt 0.4461
hsa_FBXW7_0002500 Exon-Exon chr4:153251884-153271276 chr4:152330732-152350124 207 nt 0.4396
hsa_FBXW7_0002600 Exon-Exon chr4:153251884-153333681 chr4:152330732-152412529 50 nt 0.4600
hsa_FBXW7_0002700 Exon-Exon chr4:153251961-153271246 chr4:152330809-152350094 53 nt 0.3962
hsa_FBXW7_0003000 Exon-Exon chr4:153253748-153268169 chr4:152332596-152347017 124 nt 0.4677
Showing 31 to 40 of 163 entries
Forensic Context

A study in human brain cancer demonstrated that the circFBXW7 functions as a tumor suppressor, where its expression inhibits cell progression, migration, and tumor formation [Di Agostino et al. DOI:10.3389/fcell.2020.00389]. Further research confirmed its coding potential, showing the translated peptide FBXW7-185aa reduces the half-life of c-Myc and inhibits cell cycle progression [Sema Misir et al. DOI:10.1038/s41418-022-00948-7]. The peptide FBXW7-185aa, which originates from the circFBXW7, inhibits cell cycle progression [Misir et al. DOI:10.1038/s41418-022-00948-7].