Basic Information

Symbol
circFBXW7
RNA Class
circRNA
Alias
F-Box And WD Repeat Domain Containing 7 SEL-10 SEL10 FBX30 FBW7 FBXW6 CDC4 AGO F-Box And WD Repeat Domain Containing 7, E3 Ubiquitin Protein Ligase F-Box And WD-40 Domain Protein 7 (Archipelago Homolog, Drosophila) F-Box/WD Repeat-Containing Protein 7 F-Box Protein FBX30 FLJ11071 HCdc4 HAgo F-Box And WD-40 Domain-Containing Protein 7 Archipelago Homolog (Drosophila) Homolog Of C Elegans Sel-10 F-Box Protein SEL-10 Archipelago Homolog F-Box Protein FBW7 Archipelago DEDHIL FBXO30 FBW6
Location (GRCh37)
4:153243748-153456566 UCSC Genome Browser
Location (GRCh38)
4:152322596-152535414
UCSC Genome Browser Search in Marker Scope
Host gene
FBXW7
Host category
mRNA
Forensic tag(s)
Other applications
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_FBXW7_0003100 Exon-Exon chr4:153253748-153268223 chr4:152332596-152347071 266 nt 0.4925
hsa_FBXW7_0003200 Exon-Exon chr4:153253748-153271276 chr4:152332596-152350124 360 nt 0.4444
hsa_FBXW7_0002900 Exon-Exon chr4:153253748-153333024 chr4:152332596-152411872 1054 nt 0.4526
hsa_chr4_0190300 Intergenic-Intergenic chr4:153256266-153256647 chr4:152335114-152335495 382 nt 0.4581
hsa_FBXW7_0003300 Intron-Exon-Intron chr4:153256793-153259088 chr4:152335641-152337936 2296 nt 0.2940
hsa_FBXW7_0003400 Exon-Exon chr4:153258954-153271264 chr4:152337802-152350112 348 nt 0.4511
hsa_FBXW7_0003500 Exon-Exon chr4:153258954-153271276 chr4:152337802-152350124 360 nt 0.4444
hsa_FBXW7_0003600 Exon-Exon chr4:153258954-153333024 chr4:152337802-152411872 135 nt 0.4000
hsa_FBXW7_0003700 Exon-Exon chr4:153258954-153333681 chr4:152337802-152412529 56 nt 0.4464
hsa_chr4_0190400 Intergenic-Intergenic chr4:153266257-153267092 chr4:152345105-152345940 836 nt 0.3254
Showing 41 to 50 of 163 entries
Forensic Context

A study in human brain cancer demonstrated that the circFBXW7 functions as a tumor suppressor, where its expression inhibits cell progression, migration, and tumor formation [Di Agostino et al. DOI:10.3389/fcell.2020.00389]. Further research confirmed its coding potential, showing the translated peptide FBXW7-185aa reduces the half-life of c-Myc and inhibits cell cycle progression [Sema Misir et al. DOI:10.1038/s41418-022-00948-7]. The peptide FBXW7-185aa, which originates from the circFBXW7, inhibits cell cycle progression [Misir et al. DOI:10.1038/s41418-022-00948-7].