Basic Information

Symbol
circFBXW7
RNA Class
circRNA
Alias
F-Box And WD Repeat Domain Containing 7 SEL-10 SEL10 FBX30 FBW7 FBXW6 CDC4 AGO F-Box And WD Repeat Domain Containing 7, E3 Ubiquitin Protein Ligase F-Box And WD-40 Domain Protein 7 (Archipelago Homolog, Drosophila) F-Box/WD Repeat-Containing Protein 7 F-Box Protein FBX30 FLJ11071 HCdc4 HAgo F-Box And WD-40 Domain-Containing Protein 7 Archipelago Homolog (Drosophila) Homolog Of C Elegans Sel-10 F-Box Protein SEL-10 Archipelago Homolog F-Box Protein FBW7 Archipelago DEDHIL FBXO30 FBW6
Location (GRCh37)
4:153243748-153456566 UCSC Genome Browser
Location (GRCh38)
4:152322596-152535414
UCSC Genome Browser Search in Marker Scope
Host gene
FBXW7
Host category
mRNA
Forensic tag(s)
Other applications
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_FBXW7_0003800 Intron-Intron chr4:153267764-153268081 chr4:152346612-152346929 318 nt 0.3805
hsa_FBXW7_0004200 Exon-Exon chr4:153268082-153268223 chr4:152346930-152347071 142 nt 0.5141
hsa_FBXW7_0004300 Exon-Exon chr4:153268082-153303518 chr4:152346930-152382366 403 nt 0.4467
hsa_FBXW7_0004000 Exon-Exon chr4:153268082-153333024 chr4:152346930-152411872 795 nt 0.4591
hsa_FBXW7_0004400 Exon-Exon chr4:153268082-153333681 chr4:152346930-152412529 845 nt 0.4592
hsa_FBXW7_0004500 Intron-Exon-Intron chr4:153268082-153391140 chr4:152346930-152469988 225 nt 0.4711
hsa_FBXW7_0004100 Intron-Exon-Intron chr4:153268082-153403825 chr4:152346930-152482673 250 nt 0.3560
hsa_FBXW7_0004600 Intron-Exon-Intron chr4:153271194-153271360 chr4:152350042-152350208 167 nt 0.3174
hsa_FBXW7_0004700 Intron-Intron chr4:153278555-153278810 chr4:152357403-152357658 256 nt 0.4961
hsa_chr4_0190600 Intergenic-Intergenic chr4:153278655-153280238 chr4:152357503-152359086 1584 nt 0.3428
Showing 51 to 60 of 163 entries
Forensic Context

A study in human brain cancer demonstrated that the circFBXW7 functions as a tumor suppressor, where its expression inhibits cell progression, migration, and tumor formation [Di Agostino et al. DOI:10.3389/fcell.2020.00389]. Further research confirmed its coding potential, showing the translated peptide FBXW7-185aa reduces the half-life of c-Myc and inhibits cell cycle progression [Sema Misir et al. DOI:10.1038/s41418-022-00948-7]. The peptide FBXW7-185aa, which originates from the circFBXW7, inhibits cell cycle progression [Misir et al. DOI:10.1038/s41418-022-00948-7].