Basic Information

Symbol
circFBXW7
RNA Class
circRNA
Alias
F-Box And WD Repeat Domain Containing 7 SEL-10 SEL10 FBX30 FBW7 FBXW6 CDC4 AGO F-Box And WD Repeat Domain Containing 7, E3 Ubiquitin Protein Ligase F-Box And WD-40 Domain Protein 7 (Archipelago Homolog, Drosophila) F-Box/WD Repeat-Containing Protein 7 F-Box Protein FBX30 FLJ11071 HCdc4 HAgo F-Box And WD-40 Domain-Containing Protein 7 Archipelago Homolog (Drosophila) Homolog Of C Elegans Sel-10 F-Box Protein SEL-10 Archipelago Homolog F-Box Protein FBW7 Archipelago DEDHIL FBXO30 FBW6
Location (GRCh37)
4:153243748-153456566 UCSC Genome Browser
Location (GRCh38)
4:152322596-152535414
UCSC Genome Browser Search in Marker Scope
Host gene
FBXW7
Host category
mRNA
Forensic tag(s)
Other applications
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_FBXW7_0005900 Intron-Exon-Intron chr4:153303341-153333681 chr4:152382189-152412529 798 nt 0.4461
hsa_FBXW7_0006000 Intron-Exon-Intron chr4:153303341-153348711 chr4:152382189-152427559 155 nt 0.3871
hsa_FBXW7_0005500 Intron-Exon-Intron chr4:153303341-153369658 chr4:152382189-152448506 250 nt 0.3080
hsa_FBXW7_0005600 Intron-Exon-Intron chr4:153303341-153372928 chr4:152382189-152451776 250 nt 0.3960
hsa_FBXW7_0006100 Intron-Exon-Intron chr4:153303341-153391140 chr4:152382189-152469988 276 nt 0.4130
hsa_FBXW7_0006200 Intron-Exon-Intron chr4:153303341-153403825 chr4:152382189-152482673 178 nt 0.4157
hsa_FBXW7_0006300 Intron-Intron chr4:153310008-153310171 chr4:152388856-152389019 164 nt 0.3293
hsa_FBXW7_0006400 Intron-Intron chr4:153311738-153311934 chr4:152390586-152390782 197 nt 0.2437
hsa_FBXW7_0006500 Intron-Exon chr4:153318797-153333024 chr4:152397645-152411872 41 nt 0.2927
hsa_FBXW7_0006600 Intron-Exon-Intron chr4:153318797-153333681 chr4:152397645-152412529 91 nt 0.3846
Showing 71 to 80 of 163 entries
Forensic Context

A study in human brain cancer demonstrated that the circFBXW7 functions as a tumor suppressor, where its expression inhibits cell progression, migration, and tumor formation [Di Agostino et al. DOI:10.3389/fcell.2020.00389]. Further research confirmed its coding potential, showing the translated peptide FBXW7-185aa reduces the half-life of c-Myc and inhibits cell cycle progression [Sema Misir et al. DOI:10.1038/s41418-022-00948-7]. The peptide FBXW7-185aa, which originates from the circFBXW7, inhibits cell cycle progression [Misir et al. DOI:10.1038/s41418-022-00948-7].