Basic Information
Symbol
circFBXW7
RNA Class
circRNA
Alias
F-Box And WD Repeat Domain Containing 7
SEL-10
SEL10
FBX30
FBW7
FBXW6
CDC4
AGO
F-Box And WD Repeat Domain Containing 7, E3 Ubiquitin Protein Ligase
F-Box And WD-40 Domain Protein 7 (Archipelago Homolog, Drosophila)
F-Box/WD Repeat-Containing Protein 7
F-Box Protein FBX30
FLJ11071
HCdc4
HAgo
F-Box And WD-40 Domain-Containing Protein 7
Archipelago Homolog (Drosophila)
Homolog Of C Elegans Sel-10
F-Box Protein SEL-10
Archipelago Homolog
F-Box Protein FBW7
Archipelago
DEDHIL
FBXO30
FBW6
Location (GRCh37)
4:153243748-153456566
UCSC Genome Browser
Location (GRCh38)
4:152322596-152535414
Host gene
FBXW7
Host category
mRNA
Forensic tag(s)
Other applications
External database
Transcripts
| ID | Type | Location (GRCh37) | Location (GRCh38) | Length | GC content |
|---|---|---|---|---|---|
| hsa_FBXW7_0006700 | Intron-Exon-Intron | chr4:153318797-153391140 | chr4:152397645-152469988 | 41 nt | 0.2927 |
| hsa_FBXW7_0006800 | Intron-Intron | chr4:153324807-153325231 | chr4:152403655-152404079 | 425 nt | 0.4424 |
| hsa_FBXW7_0007700 | Exon-Exon | chr4:153332455-153333024 | chr4:152411303-152411872 | 570 nt | 0.4544 |
| hsa_FBXW7_0007800 | Exon-Exon | chr4:153332455-153333667 | chr4:152411303-152412515 | 606 nt | 0.4571 |
| hsa_FBXW7_0008000 | Exon-Intron | chr4:153332455-153340853 | chr4:152411303-152419701 | 33 nt | 0.4545 |
| hsa_FBXW7_0008100 | Exon-Intron | chr4:153332455-153341119 | chr4:152411303-152419967 | 138 nt | 0.3768 |
| hsa_FBXW7_0008200 | Exon-Intron | chr4:153332455-153348711 | chr4:152411303-152427559 | 205 nt | 0.4049 |
| hsa_FBXW7_0007200 | Exon-Intron | chr4:153332455-153349776 | chr4:152411303-152428624 | 250 nt | 0.3360 |
| hsa_FBXW7_0008300 | Exon-Intron | chr4:153332455-153361772 | chr4:152411303-152440620 | 685 nt | 0.4365 |
| hsa_FBXW7_0008400 | Exon-Intron | chr4:153332455-153369658 | chr4:152411303-152448506 | 50 nt | 0.4600 |
Showing 81 to 90 of 163 entries
Forensic Context
A study in human brain cancer demonstrated that the circFBXW7 functions as a tumor suppressor, where its expression inhibits cell progression, migration, and tumor formation [Di Agostino et al. DOI:10.3389/fcell.2020.00389]. Further research confirmed its coding potential, showing the translated peptide FBXW7-185aa reduces the half-life of c-Myc and inhibits cell cycle progression [Sema Misir et al. DOI:10.1038/s41418-022-00948-7]. The peptide FBXW7-185aa, which originates from the circFBXW7, inhibits cell cycle progression [Misir et al. DOI:10.1038/s41418-022-00948-7].