Basic Information
Symbol
circFGD4
RNA Class
circRNA
Alias
FYVE, RhoGEF And PH Domain Containing 4
ZFYVE6
FRABP
CMT4H
FYVE, RhoGEF And PH Domain-Containing Protein 4
Zinc Finger FYVE Domain-Containing Protein 6
FGD1-Related F-Actin-Binding Protein
FGD1 Family, Member 4
Frabin
Actin-Filament Binding Protein Frabin
Actin Filament-Binding Protein Frabin
Location (GRCh37)
12:32553594-32797706
UCSC Genome Browser
Location (GRCh38)
12:32400660-32644772
Host gene
FGD4
Host category
mRNA
Forensic tag(s)
Sudden death from CNS diseases
Mechanical injury analysis
External database
Transcripts
| ID | Type | Location (GRCh37) | Location (GRCh38) | Length | GC content |
|---|---|---|---|---|---|
| hsa_FGD4_0004600 | Exon-Exon | chr12:32734894-32761029 | chr12:32581960-32608095 | 139 nt | 0.4460 |
| hsa_FGD4_0004900 | Exon-Exon | chr12:32734894-32777386 | chr12:32581960-32624452 | 204 nt | 0.4314 |
| hsa_FGD4_0005000 | Exon-Exon | chr12:32734894-32778002 | chr12:32581960-32625068 | 124 nt | 0.4032 |
| hsa_FGD4_0005300 | Exon-Exon | chr12:32734894-32791729 | chr12:32581960-32638795 | 141 nt | 0.4752 |
| hsa_FGD4_0005400 | Exon-Exon | chr12:32734894-32793387 | chr12:32581960-32640453 | 141 nt | 0.3475 |
| hsa_FGD4_0005500 | Exon-Exon | chr12:32735319-32755251 | chr12:32582385-32602317 | 240 nt | 0.4167 |
| hsa_FGD4_0005600 | Exon-Exon | chr12:32735344-32754357 | chr12:32582410-32601423 | 394 nt | 0.3985 |
| hsa_FGD4_0005700 | Intron-Intron | chr12:32739011-32739523 | chr12:32586077-32586589 | 513 nt | 0.3177 |
| hsa_FGD4_0005800 | Intron-Intron | chr12:32740060-32740375 | chr12:32587126-32587441 | 316 nt | 0.3797 |
| hsa_FGD4_0005900 | Intron-Exon-Intron | chr12:32743475-32764217 | chr12:32590541-32611283 | 250 nt | 0.3440 |
Showing 91 to 100 of 160 entries
Forensic Context
A study in mice demonstrated that the circFGD4 is highly expressed in the brain and spinal cord, where it functions as a miRNA sponge to regulate neuronal apoptosis and axon regeneration following spinal cord injury [Li et al. DOI:10.1016/j.neulet.2021.135795]. A study in human traumatic brain injury (TBI) patients identified the circFGD4 as a top up-regulated circular RNA (fold change 21.07) in brain injury tissues compared to adjacent contusion tissues, with its expression validated by qRT-PCR [Li et al. DOI:10.3389/fneur.2022.1086553].