Basic Information
Symbol
circFGD4
RNA Class
circRNA
Alias
FYVE, RhoGEF And PH Domain Containing 4
ZFYVE6
FRABP
CMT4H
FYVE, RhoGEF And PH Domain-Containing Protein 4
Zinc Finger FYVE Domain-Containing Protein 6
FGD1-Related F-Actin-Binding Protein
FGD1 Family, Member 4
Frabin
Actin-Filament Binding Protein Frabin
Actin Filament-Binding Protein Frabin
Location (GRCh37)
12:32553594-32797706
UCSC Genome Browser
Location (GRCh38)
12:32400660-32644772
Host gene
FGD4
Host category
mRNA
Forensic tag(s)
Sudden death from CNS diseases
Mechanical injury analysis
External database
Transcripts
| ID | Type | Location (GRCh37) | Location (GRCh38) | Length | GC content |
|---|---|---|---|---|---|
| hsa_FGD4_0007800 | Exon-Exon | chr12:32751431-32763768 | chr12:32598497-32610834 | 216 nt | 0.3565 |
| hsa_FGD4_0008000 | Exon-Exon | chr12:32751431-32778002 | chr12:32598497-32625068 | 130 nt | 0.4077 |
| hsa_FGD4_0008300 | Exon-Exon | chr12:32751431-32791729 | chr12:32598497-32638795 | 1842 nt | 0.4191 |
| hsa_FGD4_0008400 | Exon-Exon | chr12:32751431-32793387 | chr12:32598497-32640453 | 268 nt | 0.4776 |
| hsa_FGD4_0007300 | Exon-Exon | chr12:32751431-32797706 | chr12:32598497-32644772 | 250 nt | 0.2800 |
| hsa_FGD4_0008500 | Exon-Exon | chr12:32751434-32764217 | chr12:32598500-32611283 | 153 nt | 0.3660 |
| hsa_FGD4_0008600 | Exon-Exon | chr12:32751434-32778713 | chr12:32598500-32625779 | 126 nt | 0.4365 |
| hsa_FGD4_0008700 | Exon-Exon | chr12:32753344-32786623 | chr12:32600410-32633689 | 106 nt | 0.3585 |
| hsa_FGD4_0008800 | Intron-Exon | chr12:32753344-32793387 | chr12:32600410-32640453 | 1930 nt | 0.4311 |
| hsa_FGD4_0008900 | Intron-Exon-Intron | chr12:32754162-32754499 | chr12:32601228-32601565 | 338 nt | 0.3284 |
Showing 111 to 120 of 160 entries
Forensic Context
A study in mice demonstrated that the circFGD4 is highly expressed in the brain and spinal cord, where it functions as a miRNA sponge to regulate neuronal apoptosis and axon regeneration following spinal cord injury [Li et al. DOI:10.1016/j.neulet.2021.135795]. A study in human traumatic brain injury (TBI) patients identified the circFGD4 as a top up-regulated circular RNA (fold change 21.07) in brain injury tissues compared to adjacent contusion tissues, with its expression validated by qRT-PCR [Li et al. DOI:10.3389/fneur.2022.1086553].