Basic Information
Symbol
circFGD4
RNA Class
circRNA
Alias
FYVE, RhoGEF And PH Domain Containing 4
ZFYVE6
FRABP
CMT4H
FYVE, RhoGEF And PH Domain-Containing Protein 4
Zinc Finger FYVE Domain-Containing Protein 6
FGD1-Related F-Actin-Binding Protein
FGD1 Family, Member 4
Frabin
Actin-Filament Binding Protein Frabin
Actin Filament-Binding Protein Frabin
Location (GRCh37)
12:32553594-32797706
UCSC Genome Browser
Location (GRCh38)
12:32400660-32644772
Host gene
FGD4
Host category
mRNA
Forensic tag(s)
Sudden death from CNS diseases
Mechanical injury analysis
External database
Transcripts
| ID | Type | Location (GRCh37) | Location (GRCh38) | Length | GC content |
|---|---|---|---|---|---|
| hsa_FGD4_0009100 | Exon-Exon | chr12:32754212-32764217 | chr12:32601278-32611283 | 63 nt | 0.4127 |
| hsa_FGD4_0009200 | Exon-Exon | chr12:32754212-32772804 | chr12:32601278-32619870 | 476 nt | 0.3950 |
| hsa_FGD4_0009300 | Exon-Exon | chr12:32754212-32786623 | chr12:32601278-32633689 | 1305 nt | 0.4069 |
| hsa_FGD4_0009400 | Exon-Exon | chr12:32754212-32793387 | chr12:32601278-32640453 | 178 nt | 0.5281 |
| hsa_FGD4_0009500 | Exon-Exon | chr12:32754341-32755251 | chr12:32601407-32602317 | 174 nt | 0.3678 |
| hsa_FGD4_0010000 | Exon-Exon | chr12:32755095-32761029 | chr12:32602161-32608095 | 139 nt | 0.4460 |
| hsa_FGD4_0010100 | Exon-Exon | chr12:32755095-32763768 | chr12:32602161-32610834 | 157 nt | 0.3694 |
| hsa_FGD4_0010200 | Exon-Exon | chr12:32755095-32764217 | chr12:32602161-32611283 | 206 nt | 0.3592 |
| hsa_FGD4_0010300 | Exon-Exon | chr12:32755095-32777386 | chr12:32602161-32624452 | 410 nt | 0.3951 |
| hsa_FGD4_0010500 | Intron-Exon-Intron | chr12:32760872-32777386 | chr12:32607938-32624452 | 248 nt | 0.4032 |
Showing 121 to 130 of 160 entries
Forensic Context
A study in mice demonstrated that the circFGD4 is highly expressed in the brain and spinal cord, where it functions as a miRNA sponge to regulate neuronal apoptosis and axon regeneration following spinal cord injury [Li et al. DOI:10.1016/j.neulet.2021.135795]. A study in human traumatic brain injury (TBI) patients identified the circFGD4 as a top up-regulated circular RNA (fold change 21.07) in brain injury tissues compared to adjacent contusion tissues, with its expression validated by qRT-PCR [Li et al. DOI:10.3389/fneur.2022.1086553].