Basic Information
Symbol
circFGD4
RNA Class
circRNA
Alias
FYVE, RhoGEF And PH Domain Containing 4
ZFYVE6
FRABP
CMT4H
FYVE, RhoGEF And PH Domain-Containing Protein 4
Zinc Finger FYVE Domain-Containing Protein 6
FGD1-Related F-Actin-Binding Protein
FGD1 Family, Member 4
Frabin
Actin-Filament Binding Protein Frabin
Actin Filament-Binding Protein Frabin
Location (GRCh37)
12:32553594-32797706
UCSC Genome Browser
Location (GRCh38)
12:32400660-32644772
Host gene
FGD4
Host category
mRNA
Forensic tag(s)
Sudden death from CNS diseases
Mechanical injury analysis
External database
Transcripts
| ID | Type | Location (GRCh37) | Location (GRCh38) | Length | GC content |
|---|---|---|---|---|---|
| hsa_FGD4_0010600 | Intron-Exon-Intron | chr12:32760872-32778713 | chr12:32607938-32625779 | 880 nt | 0.4261 |
| hsa_FGD4_0010700 | Intron-Exon-Intron | chr12:32760872-32786623 | chr12:32607938-32633689 | 1021 nt | 0.4153 |
| hsa_FGD4_0011100 | Exon-Exon | chr12:32760891-32772804 | chr12:32607957-32619870 | 173 nt | 0.4335 |
| hsa_FGD4_0011000 | Exon-Exon | chr12:32760891-32777386 | chr12:32607957-32624452 | 549 nt | 0.4080 |
| hsa_FGD4_0011200 | Exon-Exon | chr12:32760891-32778002 | chr12:32607957-32625068 | 31 nt | 0.4194 |
| hsa_FGD4_0011300 | Exon-Exon | chr12:32760891-32786623 | chr12:32607957-32633689 | 486 nt | 0.3807 |
| hsa_FGD4_0011400 | Exon-Exon | chr12:32760891-32791729 | chr12:32607957-32638795 | 139 nt | 0.4460 |
| hsa_FGD4_0011500 | Exon-Exon | chr12:32760891-32793387 | chr12:32607957-32640453 | 1527 nt | 0.4473 |
| hsa_FGD4_0011800 | Exon-Exon | chr12:32763710-32772804 | chr12:32610776-32619870 | 173 nt | 0.4335 |
| hsa_FGD4_0011900 | Exon-Exon | chr12:32763710-32778713 | chr12:32610776-32625779 | 722 nt | 0.4252 |
Showing 131 to 140 of 160 entries
Forensic Context
A study in mice demonstrated that the circFGD4 is highly expressed in the brain and spinal cord, where it functions as a miRNA sponge to regulate neuronal apoptosis and axon regeneration following spinal cord injury [Li et al. DOI:10.1016/j.neulet.2021.135795]. A study in human traumatic brain injury (TBI) patients identified the circFGD4 as a top up-regulated circular RNA (fold change 21.07) in brain injury tissues compared to adjacent contusion tissues, with its expression validated by qRT-PCR [Li et al. DOI:10.3389/fneur.2022.1086553].