Basic Information
Symbol
circFGD4
RNA Class
circRNA
Alias
FYVE, RhoGEF And PH Domain Containing 4
ZFYVE6
FRABP
CMT4H
FYVE, RhoGEF And PH Domain-Containing Protein 4
Zinc Finger FYVE Domain-Containing Protein 6
FGD1-Related F-Actin-Binding Protein
FGD1 Family, Member 4
Frabin
Actin-Filament Binding Protein Frabin
Actin Filament-Binding Protein Frabin
Location (GRCh37)
12:32553594-32797706
UCSC Genome Browser
Location (GRCh38)
12:32400660-32644772
Host gene
FGD4
Host category
mRNA
Forensic tag(s)
Sudden death from CNS diseases
Mechanical injury analysis
External database
Transcripts
| ID | Type | Location (GRCh37) | Location (GRCh38) | Length | GC content |
|---|---|---|---|---|---|
| hsa_FGD4_0009800 | Exon-Exon | chr12:32755095-32778713 | chr12:32602161-32625779 | 925 nt | 0.4043 |
| hsa_FGD4_0009900 | Exon-Exon | chr12:32755095-32786623 | chr12:32602161-32633689 | 1066 nt | 0.3968 |
| hsa_FGD4_0010400 | Intron-Exon-Intron | chr12:32760872-32764217 | chr12:32607938-32611283 | 364 nt | 0.3901 |
| hsa_FGD4_0010800 | Exon-Exon | chr12:32760891-32764217 | chr12:32607957-32611283 | 345 nt | 0.3942 |
| hsa_FGD4_0010900 | Exon-Exon | chr12:32760891-32778713 | chr12:32607957-32625779 | 768 nt | 0.4115 |
| hsa_FGD4_0011600 | Exon-Exon | chr12:32760897-32764217 | chr12:32607963-32611283 | 339 nt | 0.3953 |
| hsa_FGD4_0011700 | Exon-Exon | chr12:32763710-32764217 | chr12:32610776-32611283 | 206 nt | 0.3592 |
| hsa_FGD4_0012000 | Exon-Exon | chr12:32764071-32778002 | chr12:32611137-32625068 | 444 nt | 0.4054 |
| hsa_chr12_0311000 | Intergenic-Intergenic | chr12:32764077-32778663 | chr12:32611143-32625729 | 250 nt | 0.2880 |
| hsa_FGD4_0012100 | Exon-Exon | chr12:32772632-32777386 | chr12:32619698-32624452 | 204 nt | 0.4314 |
Showing 21 to 30 of 160 entries
Forensic Context
A study in mice demonstrated that the circFGD4 is highly expressed in the brain and spinal cord, where it functions as a miRNA sponge to regulate neuronal apoptosis and axon regeneration following spinal cord injury [Li et al. DOI:10.1016/j.neulet.2021.135795]. A study in human traumatic brain injury (TBI) patients identified the circFGD4 as a top up-regulated circular RNA (fold change 21.07) in brain injury tissues compared to adjacent contusion tissues, with its expression validated by qRT-PCR [Li et al. DOI:10.3389/fneur.2022.1086553].