Basic Information
Symbol
circFGD4
RNA Class
circRNA
Alias
FYVE, RhoGEF And PH Domain Containing 4
ZFYVE6
FRABP
CMT4H
FYVE, RhoGEF And PH Domain-Containing Protein 4
Zinc Finger FYVE Domain-Containing Protein 6
FGD1-Related F-Actin-Binding Protein
FGD1 Family, Member 4
Frabin
Actin-Filament Binding Protein Frabin
Actin Filament-Binding Protein Frabin
Location (GRCh37)
12:32553594-32797706
UCSC Genome Browser
Location (GRCh38)
12:32400660-32644772
Host gene
FGD4
Host category
mRNA
Forensic tag(s)
Sudden death from CNS diseases
Mechanical injury analysis
External database
Transcripts
| ID | Type | Location (GRCh37) | Location (GRCh38) | Length | GC content |
|---|---|---|---|---|---|
| hsa_FGD4_0012200 | Exon-Exon | chr12:32772632-32778002 | chr12:32619698-32625068 | 297 nt | 0.4209 |
| hsa_FGD4_0012300 | Exon-Exon | chr12:32772632-32786623 | chr12:32619698-32633689 | 564 nt | 0.4060 |
| hsa_chr12_0311700 | Intergenic-Intergenic | chr12:32794560-32794833 | chr12:32641626-32641899 | 274 nt | 0.3577 |
| hsa_RNU6-494P_0000100 | Intergenic-Exon-Intergenic | chr12:32621091-32677640 | chr12:32468157-32524706 | 250 nt | 0.3520 |
| hsa_FGD4_0000100 | Intron-Intron | chr12:32553594-32553922 | chr12:32400660-32400988 | 329 nt | 0.3465 |
| hsa_FGD4_0000200 | Intron-Intron | chr12:32559396-32562317 | chr12:32406462-32409383 | 2922 nt | 0.4487 |
| hsa_chr12_0309400 | Intergenic-Intergenic | chr12:32560305-32604577 | chr12:32407371-32451643 | 250 nt | 0.3560 |
| hsa_FGD4_0000300 | Intron-Intron | chr12:32564376-32570486 | chr12:32411442-32417552 | 250 nt | 0.4320 |
| hsa_FGD4_0000400 | Intron-Intron | chr12:32564817-32586377 | chr12:32411883-32433443 | 250 nt | 0.4040 |
| hsa_FGD4_0000500 | Intron-Intron | chr12:32564845-32565553 | chr12:32411911-32412619 | 709 nt | 0.4175 |
Showing 31 to 40 of 160 entries
Forensic Context
A study in mice demonstrated that the circFGD4 is highly expressed in the brain and spinal cord, where it functions as a miRNA sponge to regulate neuronal apoptosis and axon regeneration following spinal cord injury [Li et al. DOI:10.1016/j.neulet.2021.135795]. A study in human traumatic brain injury (TBI) patients identified the circFGD4 as a top up-regulated circular RNA (fold change 21.07) in brain injury tissues compared to adjacent contusion tissues, with its expression validated by qRT-PCR [Li et al. DOI:10.3389/fneur.2022.1086553].