Basic Information
Symbol
circFGD4
RNA Class
circRNA
Alias
FYVE, RhoGEF And PH Domain Containing 4
ZFYVE6
FRABP
CMT4H
FYVE, RhoGEF And PH Domain-Containing Protein 4
Zinc Finger FYVE Domain-Containing Protein 6
FGD1-Related F-Actin-Binding Protein
FGD1 Family, Member 4
Frabin
Actin-Filament Binding Protein Frabin
Actin Filament-Binding Protein Frabin
Location (GRCh37)
12:32553594-32797706
UCSC Genome Browser
Location (GRCh38)
12:32400660-32644772
Host gene
FGD4
Host category
mRNA
Forensic tag(s)
Sudden death from CNS diseases
Mechanical injury analysis
External database
Transcripts
| ID | Type | Location (GRCh37) | Location (GRCh38) | Length | GC content |
|---|---|---|---|---|---|
| hsa_chr12_0309500 | Intergenic-Intergenic | chr12:32565466-32569182 | chr12:32412532-32416248 | 250 nt | 0.3880 |
| hsa_chr12_0309600 | Intergenic-Intergenic | chr12:32572603-32572820 | chr12:32419669-32419886 | 218 nt | 0.5505 |
| hsa_FGD4_0000600 | Intron-Intron | chr12:32583150-32586377 | chr12:32430216-32433443 | 250 nt | 0.3920 |
| hsa_chr12_0309700 | Intergenic-Intergenic | chr12:32583165-32586364 | chr12:32430231-32433430 | 250 nt | 0.3520 |
| hsa_FGD4_0000700 | Intron-Intron | chr12:32583178-32586333 | chr12:32430244-32433399 | 250 nt | 0.3000 |
| hsa_FGD4_0000800 | Intron-Intron | chr12:32584697-32597696 | chr12:32431763-32444762 | 250 nt | 0.2520 |
| hsa_FGD4_0000900 | Intron-Intron | chr12:32611206-32611343 | chr12:32458272-32458409 | 138 nt | 0.4638 |
| hsa_chr12_0309800 | Intergenic-Intergenic | chr12:32615173-32615551 | chr12:32462239-32462617 | 379 nt | 0.4380 |
| hsa_FGD4_0001000 | Intron-Intron | chr12:32618242-32626677 | chr12:32465308-32473743 | 250 nt | 0.4040 |
| hsa_FGD4_0001100 | Intron-Intron | chr12:32624193-32625029 | chr12:32471259-32472095 | 837 nt | 0.4444 |
Showing 41 to 50 of 160 entries
Forensic Context
A study in mice demonstrated that the circFGD4 is highly expressed in the brain and spinal cord, where it functions as a miRNA sponge to regulate neuronal apoptosis and axon regeneration following spinal cord injury [Li et al. DOI:10.1016/j.neulet.2021.135795]. A study in human traumatic brain injury (TBI) patients identified the circFGD4 as a top up-regulated circular RNA (fold change 21.07) in brain injury tissues compared to adjacent contusion tissues, with its expression validated by qRT-PCR [Li et al. DOI:10.3389/fneur.2022.1086553].