Basic Information
Symbol
circFGD4
RNA Class
circRNA
Alias
FYVE, RhoGEF And PH Domain Containing 4
ZFYVE6
FRABP
CMT4H
FYVE, RhoGEF And PH Domain-Containing Protein 4
Zinc Finger FYVE Domain-Containing Protein 6
FGD1-Related F-Actin-Binding Protein
FGD1 Family, Member 4
Frabin
Actin-Filament Binding Protein Frabin
Actin Filament-Binding Protein Frabin
Location (GRCh37)
12:32553594-32797706
UCSC Genome Browser
Location (GRCh38)
12:32400660-32644772
Host gene
FGD4
Host category
mRNA
Forensic tag(s)
Sudden death from CNS diseases
Mechanical injury analysis
External database
Transcripts
| ID | Type | Location (GRCh37) | Location (GRCh38) | Length | GC content |
|---|---|---|---|---|---|
| hsa_FGD4_0002400 | Exon-Exon | chr12:32717071-32735401 | chr12:32564137-32582467 | 153 nt | 0.4967 |
| hsa_FGD4_0002200 | Exon-Exon | chr12:32717071-32751520 | chr12:32564137-32598586 | 935 nt | 0.4695 |
| hsa_FGD4_0002500 | Exon-Exon | chr12:32717071-32764217 | chr12:32564137-32611283 | 153 nt | 0.4967 |
| hsa_FGD4_0002600 | Exon-Exon | chr12:32717071-32793387 | chr12:32564137-32640453 | 153 nt | 0.4967 |
| hsa_FGD4_0002700 | Intron-Intron | chr12:32724604-32724786 | chr12:32571670-32571852 | 183 nt | 0.4645 |
| hsa_FGD4_0002800 | Intron-Exon-Intron | chr12:32727660-32764217 | chr12:32574726-32611283 | 206 nt | 0.3592 |
| hsa_FGD4_0002900 | Intron-Exon-Intron | chr12:32727666-32764217 | chr12:32574732-32611283 | 284 nt | 0.4225 |
| hsa_FGD4_0003200 | Exon-Exon | chr12:32729200-32735401 | chr12:32576266-32582467 | 508 nt | 0.4843 |
| hsa_FGD4_0003100 | Exon-Exon | chr12:32729200-32751520 | chr12:32576266-32598586 | 782 nt | 0.4642 |
| hsa_FGD4_0003300 | Exon-Exon | chr12:32729200-32754357 | chr12:32576266-32601423 | 1028 nt | 0.4416 |
Showing 71 to 80 of 160 entries
Forensic Context
A study in mice demonstrated that the circFGD4 is highly expressed in the brain and spinal cord, where it functions as a miRNA sponge to regulate neuronal apoptosis and axon regeneration following spinal cord injury [Li et al. DOI:10.1016/j.neulet.2021.135795]. A study in human traumatic brain injury (TBI) patients identified the circFGD4 as a top up-regulated circular RNA (fold change 21.07) in brain injury tissues compared to adjacent contusion tissues, with its expression validated by qRT-PCR [Li et al. DOI:10.3389/fneur.2022.1086553].