Basic Information
Symbol
circFGD4
RNA Class
circRNA
Alias
FYVE, RhoGEF And PH Domain Containing 4
ZFYVE6
FRABP
CMT4H
FYVE, RhoGEF And PH Domain-Containing Protein 4
Zinc Finger FYVE Domain-Containing Protein 6
FGD1-Related F-Actin-Binding Protein
FGD1 Family, Member 4
Frabin
Actin-Filament Binding Protein Frabin
Actin Filament-Binding Protein Frabin
Location (GRCh37)
12:32553594-32797706
UCSC Genome Browser
Location (GRCh38)
12:32400660-32644772
Host gene
FGD4
Host category
mRNA
Forensic tag(s)
Sudden death from CNS diseases
Mechanical injury analysis
External database
Transcripts
| ID | Type | Location (GRCh37) | Location (GRCh38) | Length | GC content |
|---|---|---|---|---|---|
| hsa_FGD4_0003500 | Exon-Exon | chr12:32729200-32772804 | chr12:32576266-32619870 | 1722 nt | 0.4233 |
| hsa_FGD4_0003600 | Exon-Exon | chr12:32729200-32778713 | chr12:32576266-32625779 | 132 nt | 0.4470 |
| hsa_FGD4_0003700 | Exon-Exon | chr12:32729200-32786623 | chr12:32576266-32633689 | 141 nt | 0.3475 |
| hsa_FGD4_0003800 | Exon-Exon | chr12:32729200-32793387 | chr12:32576266-32640453 | 294 nt | 0.4184 |
| hsa_FGD4_0003900 | Intron-Intron | chr12:32731623-32732075 | chr12:32578689-32579141 | 453 nt | 0.4415 |
| hsa_FGD4_0004000 | Intron-Exon-Intron | chr12:32733016-32778713 | chr12:32580082-32625779 | 250 nt | 0.3400 |
| hsa_FGD4_0004200 | Exon-Exon | chr12:32734894-32735401 | chr12:32581960-32582467 | 508 nt | 0.4843 |
| hsa_FGD4_0004100 | Intron-Exon-Intron | chr12:32734894-32750142 | chr12:32581960-32597208 | 250 nt | 0.2800 |
| hsa_FGD4_0004300 | Exon-Exon | chr12:32734894-32751520 | chr12:32581960-32598586 | 90 nt | 0.3778 |
| hsa_FGD4_0004400 | Exon-Exon | chr12:32734894-32754357 | chr12:32581960-32601423 | 844 nt | 0.4396 |
Showing 81 to 90 of 160 entries
Forensic Context
A study in mice demonstrated that the circFGD4 is highly expressed in the brain and spinal cord, where it functions as a miRNA sponge to regulate neuronal apoptosis and axon regeneration following spinal cord injury [Li et al. DOI:10.1016/j.neulet.2021.135795]. A study in human traumatic brain injury (TBI) patients identified the circFGD4 as a top up-regulated circular RNA (fold change 21.07) in brain injury tissues compared to adjacent contusion tissues, with its expression validated by qRT-PCR [Li et al. DOI:10.3389/fneur.2022.1086553].