Basic Information

Symbol
circFLI1
RNA Class
circRNA
Alias
Fli-1 Proto-Oncogene, ETS Transcription Factor SIC-1 EWSR2 FLI-1 Friend Leukemia Integration 1 Transcription Factor Friend Leukemia Virus Integration 1 Transcription Factor ERGB Ewing Sarcoma Breakpoint Region 2 Proto-Oncogene Fli-1 BDPLT21
Location (GRCh37)
11:128628010-128638167 UCSC Genome Browser
Location (GRCh38)
11:128758115-128768272
UCSC Genome Browser Search in Marker Scope
Host gene
FLI1
Host category
mRNA
Forensic tag(s)
Chronological age estimation Sudden death from respiratory system disease Sudden cardiac death diagnosis
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_FLI1_0001200 Exon-Exon chr11:128628010-128638167 chr11:128758115-128768272 367 nt 0.5995
Forensic Context

A study in humans demonstrated that circFLI1 is specifically expressed in peripheral blood and is associated with aging, where its levels are elevated in aged individuals [Misir et al. DOI:10.1038/s41418-022-00948-7]. A study in humans identified the circFLI1 as an intronic circRNA that is significantly up-regulated and co-differentially expressed in both plasma and lung tissue from patients with sepsis-induced acute respiratory distress syndrome [Guo et al. DOI:10.1016/j.lfs.2021.119566]. Separately, research on human coronary arteries from a postmortem case demonstrated that circFLI1 shows differential expression correlating with the anatomical severity of atherosclerosis, establishing their pathological role in coronary artery disease [Hou et al. DOI:10.1002/jcla.23552].