Forensic RNA Knowledge Base

Basic Information

Symbol

circFOXO1

RNA Class

circRNA

Alias

Forkhead Box O1 FOXO1A FKH1 FKHR Forkhead Box Protein O1A Forkhead Box Protein O1 Forkhead, Drosophila, Homolog Of, In Rhabdomyosarcoma Forkhead Homolog In Rhabdomyosarcoma Forkhead In Rhabdomyosarcoma

Location (GRCh37)

13:41133646-41134997 UCSC Genome Browser

Location (GRCh38)

13:40559509-40560860

UCSC Genome Browser Search in Marker Scope

Host gene

FOXO1

Host category

mRNA

Forensic tag(s)

Sudden cardiac death diagnosis

External database

circbank

Transcripts

ID	Type	Location (GRCh37)	Location (GRCh38)	Length	GC content
hsa_FOXO1_0001600	Exon-Exon	chr13:41133646-41134997	chr13:40559509-40560860	1352 nt	0.5044

Forensic Context

A study in mice demonstrated that the circFOXO1 promotes cardiac senescence by interacting with ID-1, E2F1, FAK, and HIF1α [Huang et al. DOI:10.3390/cells11091381]. A review of studies in humans, mice, and rats indicates that the circFOXO1 is differentially expressed in peripheral blood mononuclear cells of patients with coronary artery disease [Tian et al. DOI:10.3390/molecules26041155].