Basic Information

Symbol
circFOXO3
RNA Class
circRNA
Alias
Forkhead Box O3 AF6q21 FKHRL1 FOXO3A FOXO2 Forkhead In Rhabdomyosarcoma-Like 1 Forkhead Box Protein O3 Forkhead, Drosophila, Homolog Of, In Rhabdomyosarcoma-Like 1 Forkhead Homolog (Rhabdomyosarcoma) Like 1 Forkhead Box O3A AF6q21 Protein FKHRL1P2 FOXO3A-
Location (GRCh37)
6:108882254-109004096 UCSC Genome Browser
Location (GRCh38)
6:108561051-108682893
UCSC Genome Browser Search in Marker Scope
Host gene
Foxo3
Host category
mRNA
Forensic tag(s)
Chronological age estimation
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_FOXO3_0001000 Intron-Intron chr6:108888375-108890945 chr6:108567172-108569742 2571 nt 0.4597
hsa_FOXO3_0004700 Exon-Exon chr6:108984658-108986092 chr6:108663455-108664889 1435 nt 0.5645
hsa_SUMO2P8_0000100 Intergenic-Exon-Intergenic chr6:108882889-108985095 chr6:108561686-108663892 582 nt 0.6014
hsa_chr6_0029500 Intergenic-Intergenic chr6:108882254-108882986 chr6:108561051-108561783 733 nt 0.7326
hsa_FOXO3_0000200 Exon-Exon chr6:108882289-108883032 chr6:108561086-108561829 744 nt 0.7325
hsa_FOXO3_0000100 Exon-Exon chr6:108882289-108986092 chr6:108561086-108664889 2179 nt 0.6218
hsa_chr6_0029600 Intergenic-Intergenic chr6:108883644-108883895 chr6:108562441-108562692 252 nt 0.6151
hsa_FOXO3_0000300 Intron-Intron chr6:108885857-108886490 chr6:108564654-108565287 634 nt 0.3565
hsa_FOXO3_0000400 Intron-Intron chr6:108886315-108969305 chr6:108565112-108648102 250 nt 0.3920
hsa_FOXO3_0000500 Intron-Intron chr6:108887291-108890945 chr6:108566088-108569742 250 nt 0.4080
Showing 1 to 10 of 66 entries
Forensic Context

A study in humans demonstrated that the circFOXO3 is specifically expressed in the peripheral blood of aged people and is highly expressed in aged tissues, where it promotes cellular aging and decreases cardiac functions [Sema Misir et al. DOI:10.1038/s41418-022-00948-7]. This circRNA also regulates cell growth by sponging miRNAs and serves as a scaffold forming a ternary complex with p21 and CDK2 to block cell cycle progression [Ines Lucia Patop et al. DOI:10.15252/embj.2018100836].