Basic Information

Symbol
circFOXO3
RNA Class
circRNA
Alias
Forkhead Box O3 AF6q21 FKHRL1 FOXO3A FOXO2 Forkhead In Rhabdomyosarcoma-Like 1 Forkhead Box Protein O3 Forkhead, Drosophila, Homolog Of, In Rhabdomyosarcoma-Like 1 Forkhead Homolog (Rhabdomyosarcoma) Like 1 Forkhead Box O3A AF6q21 Protein FKHRL1P2 FOXO3A-
Location (GRCh37)
6:108882254-109004096 UCSC Genome Browser
Location (GRCh38)
6:108561051-108682893
UCSC Genome Browser Search in Marker Scope
Host gene
Foxo3
Host category
mRNA
Forensic tag(s)
Chronological age estimation
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_FOXO3_0000600 Intron-Intron chr6:108887734-108891741 chr6:108566531-108570538 250 nt 0.3640
hsa_FOXO3_0000700 Intron-Intron chr6:108887920-108890945 chr6:108566717-108569742 250 nt 0.4120
hsa_FOXO3_0000900 Intron-Intron chr6:108887982-108890945 chr6:108566779-108569742 661 nt 0.4750
hsa_FOXO3_0000800 Intron-Intron chr6:108887982-108911626 chr6:108566779-108590423 250 nt 0.3080
hsa_FOXO3_0001400 Intron-Intron chr6:108888375-108888752 chr6:108567172-108567549 378 nt 0.4683
hsa_FOXO3_0001100 Intron-Intron chr6:108888375-108918289 chr6:108567172-108597086 250 nt 0.3520
hsa_FOXO3_0001200 Intron-Intron chr6:108888375-108942953 chr6:108567172-108621750 250 nt 0.3840
hsa_FOXO3_0001300 Intron-Exon-Intron chr6:108888375-108986092 chr6:108567172-108664889 250 nt 0.4120
hsa_chr6_0029700 Intergenic-Intergenic chr6:108889638-108889926 chr6:108568435-108568723 289 nt 0.4152
hsa_chr6_0029800 Intergenic-Intergenic chr6:108889668-108890085 chr6:108568465-108568882 418 nt 0.4282
Showing 11 to 20 of 66 entries
Forensic Context

A study in humans demonstrated that the circFOXO3 is specifically expressed in the peripheral blood of aged people and is highly expressed in aged tissues, where it promotes cellular aging and decreases cardiac functions [Sema Misir et al. DOI:10.1038/s41418-022-00948-7]. This circRNA also regulates cell growth by sponging miRNAs and serves as a scaffold forming a ternary complex with p21 and CDK2 to block cell cycle progression [Ines Lucia Patop et al. DOI:10.15252/embj.2018100836].