Basic Information

Symbol
circFOXO3
RNA Class
circRNA
Alias
Forkhead Box O3 AF6q21 FKHRL1 FOXO3A FOXO2 Forkhead In Rhabdomyosarcoma-Like 1 Forkhead Box Protein O3 Forkhead, Drosophila, Homolog Of, In Rhabdomyosarcoma-Like 1 Forkhead Homolog (Rhabdomyosarcoma) Like 1 Forkhead Box O3A AF6q21 Protein FKHRL1P2 FOXO3A-
Location (GRCh37)
6:108882254-109004096 UCSC Genome Browser
Location (GRCh38)
6:108561051-108682893
UCSC Genome Browser Search in Marker Scope
Host gene
Foxo3
Host category
mRNA
Forensic tag(s)
Chronological age estimation
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_FOXO3_0001500 Intron-Intron chr6:108890032-108890945 chr6:108568829-108569742 914 nt 0.4212
hsa_FOXO3_0001600 Intron-Exon-Intron chr6:108890765-108986092 chr6:108569562-108664889 181 nt 0.5138
hsa_FOXO3_0001700 Intron-Intron chr6:108893259-108893449 chr6:108572056-108572246 191 nt 0.4921
hsa_FOXO3_0001800 Intron-Intron chr6:108895917-108896072 chr6:108574714-108574869 156 nt 0.3205
hsa_chr6_0029900 Intergenic-Intergenic chr6:108908475-108909164 chr6:108587272-108587961 690 nt 0.4551
hsa_FOXO3_0002000 Intron-Intron chr6:108909553-108909871 chr6:108588350-108588668 319 nt 0.3260
hsa_FOXO3_0002100 Intron-Intron chr6:108909553-108910173 chr6:108588350-108588970 621 nt 0.3833
hsa_FOXO3_0002200 Intron-Intron chr6:108909553-108910337 chr6:108588350-108589134 149 nt 0.4094
hsa_FOXO3_0001900 Intron-Intron chr6:108909553-108911626 chr6:108588350-108590423 2074 nt 0.4127
hsa_FOXO3_0002300 Intron-Intron chr6:108909553-108911711 chr6:108588350-108590508 33 nt 0.2424
Showing 21 to 30 of 66 entries
Forensic Context

A study in humans demonstrated that the circFOXO3 is specifically expressed in the peripheral blood of aged people and is highly expressed in aged tissues, where it promotes cellular aging and decreases cardiac functions [Sema Misir et al. DOI:10.1038/s41418-022-00948-7]. This circRNA also regulates cell growth by sponging miRNAs and serves as a scaffold forming a ternary complex with p21 and CDK2 to block cell cycle progression [Ines Lucia Patop et al. DOI:10.15252/embj.2018100836].