Basic Information

Symbol
circFOXO3
RNA Class
circRNA
Alias
Forkhead Box O3 AF6q21 FKHRL1 FOXO3A FOXO2 Forkhead In Rhabdomyosarcoma-Like 1 Forkhead Box Protein O3 Forkhead, Drosophila, Homolog Of, In Rhabdomyosarcoma-Like 1 Forkhead Homolog (Rhabdomyosarcoma) Like 1 Forkhead Box O3A AF6q21 Protein FKHRL1P2 FOXO3A-
Location (GRCh37)
6:108882254-109004096 UCSC Genome Browser
Location (GRCh38)
6:108561051-108682893
UCSC Genome Browser Search in Marker Scope
Host gene
Foxo3
Host category
mRNA
Forensic tag(s)
Chronological age estimation
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_FOXO3_0002400 Intron-Intron chr6:108909553-108915701 chr6:108588350-108594498 99 nt 0.4141
hsa_FOXO3_0002500 Intron-Intron chr6:108909553-108925908 chr6:108588350-108604705 214 nt 0.3692
hsa_FOXO3_0002600 Intron-Intron chr6:108909553-108938808 chr6:108588350-108617605 72 nt 0.2639
hsa_FOXO3_0002700 Intron-Intron chr6:108909553-108941595 chr6:108588350-108620392 33 nt 0.2424
hsa_FOXO3_0002800 Intron-Intron chr6:108915158-108943184 chr6:108593955-108621981 250 nt 0.4360
hsa_FOXO3_0002900 Intron-Intron chr6:108915200-108921460 chr6:108593997-108600257 250 nt 0.3040
hsa_FOXO3_0003000 Intron-Intron chr6:108915636-108916418 chr6:108594433-108595215 143 nt 0.4406
hsa_FOXO3_0003100 Intron-Intron chr6:108915636-108969305 chr6:108594433-108648102 224 nt 0.4643
hsa_FOXO3_0003200 Intron-Intron chr6:108918196-108941595 chr6:108596993-108620392 132 nt 0.3939
hsa_chr6_0030000 Intergenic-Intergenic chr6:108920947-108921135 chr6:108599744-108599932 189 nt 0.4074
Showing 31 to 40 of 66 entries
Forensic Context

A study in humans demonstrated that the circFOXO3 is specifically expressed in the peripheral blood of aged people and is highly expressed in aged tissues, where it promotes cellular aging and decreases cardiac functions [Sema Misir et al. DOI:10.1038/s41418-022-00948-7]. This circRNA also regulates cell growth by sponging miRNAs and serves as a scaffold forming a ternary complex with p21 and CDK2 to block cell cycle progression [Ines Lucia Patop et al. DOI:10.15252/embj.2018100836].