Basic Information

Symbol
circFOXO3
RNA Class
circRNA
Alias
Forkhead Box O3 AF6q21 FKHRL1 FOXO3A FOXO2 Forkhead In Rhabdomyosarcoma-Like 1 Forkhead Box Protein O3 Forkhead, Drosophila, Homolog Of, In Rhabdomyosarcoma-Like 1 Forkhead Homolog (Rhabdomyosarcoma) Like 1 Forkhead Box O3A AF6q21 Protein FKHRL1P2 FOXO3A-
Location (GRCh37)
6:108882254-109004096 UCSC Genome Browser
Location (GRCh38)
6:108561051-108682893
UCSC Genome Browser Search in Marker Scope
Host gene
Foxo3
Host category
mRNA
Forensic tag(s)
Chronological age estimation
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_FOXO3_0003300 Intron-Intron chr6:108925650-108926597 chr6:108604447-108605394 948 nt 0.3956
hsa_FOXO3_0003400 Intron-Intron chr6:108927305-108927572 chr6:108606102-108606369 268 nt 0.4440
hsa_FOXO3_0003500 Intron-Intron chr6:108928849-108931723 chr6:108607646-108610520 2875 nt 0.3930
hsa_FOXO3_0003600 Intron-Intron chr6:108946906-108947091 chr6:108625703-108625888 186 nt 0.4839
hsa_FOXO3_0003700 Intron-Intron chr6:108949769-108950636 chr6:108628566-108629433 868 nt 0.4551
hsa_FOXO3_0003800 Intron-Intron chr6:108951471-108952517 chr6:108630268-108631314 1047 nt 0.3945
hsa_chr6_0030100 Intergenic-Intergenic chr6:108952059-108952618 chr6:108630856-108631415 560 nt 0.3661
hsa_FOXO3_0003900 Intron-Intron chr6:108959524-108969305 chr6:108638321-108648102 186 nt 0.4516
hsa_FOXO3_0004000 Intron-Exon-Intron chr6:108960171-108986092 chr6:108638968-108664889 250 nt 0.4600
hsa_FOXO3_0004100 Intron-Intron chr6:108966327-108968596 chr6:108645124-108647393 2270 nt 0.3687
Showing 41 to 50 of 66 entries
Forensic Context

A study in humans demonstrated that the circFOXO3 is specifically expressed in the peripheral blood of aged people and is highly expressed in aged tissues, where it promotes cellular aging and decreases cardiac functions [Sema Misir et al. DOI:10.1038/s41418-022-00948-7]. This circRNA also regulates cell growth by sponging miRNAs and serves as a scaffold forming a ternary complex with p21 and CDK2 to block cell cycle progression [Ines Lucia Patop et al. DOI:10.15252/embj.2018100836].