Basic Information

Symbol
circFOXO3
RNA Class
circRNA
Alias
Forkhead Box O3 AF6q21 FKHRL1 FOXO3A FOXO2 Forkhead In Rhabdomyosarcoma-Like 1 Forkhead Box Protein O3 Forkhead, Drosophila, Homolog Of, In Rhabdomyosarcoma-Like 1 Forkhead Homolog (Rhabdomyosarcoma) Like 1 Forkhead Box O3A AF6q21 Protein FKHRL1P2 FOXO3A-
Location (GRCh37)
6:108882254-109004096 UCSC Genome Browser
Location (GRCh38)
6:108561051-108682893
UCSC Genome Browser Search in Marker Scope
Host gene
Foxo3
Host category
mRNA
Forensic tag(s)
Chronological age estimation
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_FOXO3_0004300 Intron-Intron chr6:108966327-108969305 chr6:108645124-108648102 288 nt 0.4271
hsa_FOXO3_0004200 Intron-Intron chr6:108966327-108969966 chr6:108645124-108648763 250 nt 0.3480
hsa_chr6_0030200 Intergenic-Intergenic chr6:108971192-108971990 chr6:108649989-108650787 799 nt 0.4318
hsa_FOXO3_0004400 Intron-Intron chr6:108975229-108975417 chr6:108654026-108654214 189 nt 0.5608
hsa_FOXO3_0004500 Intron-Intron chr6:108977498-108977741 chr6:108656295-108656538 120 nt 0.5167
hsa_FOXO3_0004600 Intron-Intron chr6:108979862-108981842 chr6:108658659-108660639 1981 nt 0.4124
hsa_FOXO3_0004800 Intron-Exon-Intron chr6:108984658-108989702 chr6:108663455-108668499 250 nt 0.4240
hsa_FOXO3_0004900 Exon-Exon chr6:108984658-109001308 chr6:108663455-108680105 1714 nt 0.5548
hsa_chr6_0030300 Intergenic-Intergenic chr6:108985831-108986324 chr6:108664628-108665121 494 nt 0.5000
hsa_chr6_0030400 Intergenic-Intergenic chr6:108987779-108990068 chr6:108666576-108668865 2290 nt 0.4245
Showing 51 to 60 of 66 entries
Forensic Context

A study in humans demonstrated that the circFOXO3 is specifically expressed in the peripheral blood of aged people and is highly expressed in aged tissues, where it promotes cellular aging and decreases cardiac functions [Sema Misir et al. DOI:10.1038/s41418-022-00948-7]. This circRNA also regulates cell growth by sponging miRNAs and serves as a scaffold forming a ternary complex with p21 and CDK2 to block cell cycle progression [Ines Lucia Patop et al. DOI:10.15252/embj.2018100836].