Basic Information
Symbol
circFOXO3
RNA Class
circRNA
Alias
Forkhead Box O3
AF6q21
FKHRL1
FOXO3A
FOXO2
Forkhead In Rhabdomyosarcoma-Like 1
Forkhead Box Protein O3
Forkhead, Drosophila, Homolog Of, In Rhabdomyosarcoma-Like 1
Forkhead Homolog (Rhabdomyosarcoma) Like 1
Forkhead Box O3A
AF6q21 Protein
FKHRL1P2
FOXO3A-
Location (GRCh37)
6:108882254-109004096
UCSC Genome Browser
Location (GRCh38)
6:108561051-108682893
Host gene
Foxo3
Host category
mRNA
Forensic tag(s)
Chronological age estimation
External database
Transcripts
| ID | Type | Location (GRCh37) | Location (GRCh38) | Length | GC content |
|---|---|---|---|---|---|
| hsa_FOXO3_0005100 | Exon-Exon | chr6:109001485-109002328 | chr6:108680282-108681125 | 844 nt | 0.3934 |
| hsa_chr6_0030500 | Intergenic-Intergenic | chr6:109001570-109004096 | chr6:108680367-108682893 | 2527 nt | 0.4341 |
| hsa_chr6_0030600 | Intergenic-Intergenic | chr6:109002056-109003430 | chr6:108680853-108682227 | 1375 nt | 0.4102 |
| hsa_chr6_0030700 | Intergenic-Intergenic | chr6:109002083-109003016 | chr6:108680880-108681813 | 934 nt | 0.3929 |
| hsa_FOXO3_0005200 | Exon-Exon | chr6:109003558-109003924 | chr6:108682355-108682721 | 367 nt | 0.5341 |
| hsa_chr6_0030800 | Intergenic-Intergenic | chr6:109003634-109003814 | chr6:108682431-108682611 | 181 nt | 0.5967 |
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Forensic Context
A study in humans demonstrated that the circFOXO3 is specifically expressed in the peripheral blood of aged people and is highly expressed in aged tissues, where it promotes cellular aging and decreases cardiac functions [Sema Misir et al. DOI:10.1038/s41418-022-00948-7]. This circRNA also regulates cell growth by sponging miRNAs and serves as a scaffold forming a ternary complex with p21 and CDK2 to block cell cycle progression [Ines Lucia Patop et al. DOI:10.15252/embj.2018100836].