Basic Information

Symbol
circALAS2
RNA Class
circRNA
Alias
5''-Aminolevulinate Synthase 2 ALAS-E 5'-Aminolevulinate Synthase 2 ASB 5-Aminolevulinate Synthase, Erythroid-Specific, Mitochondrial Erythroid-Specific Delta-Aminolevulinate Synthase Aminolevulinate, Delta-, Synthase 2 5-Aminolevulinic Acid Synthase 2 Delta-Aminolevulinate Synthase 2 Delta-ALA Synthase 2 EC 2.3.1.37 ALASE Aminolevulinate, Delta-, Synthase 2 (Sideroblastic/Hypochromic Anemia) Sideroblastic/Hypochromic Anemia Delta-ALA Synthetase SIDBA1 XLDPP XLEPP ANH1 XLSA
Location (GRCh37)
X:55035488-55052396 UCSC Genome Browser
Location (GRCh38)
X:55009055-55025963
UCSC Genome Browser Search in Marker Scope
Host gene
ALAS2
Host category
mRNA
Forensic tag(s)
Tissue/body fluid identification
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_ALAS2_0000100 Exon-Exon chrX:55035488-55042175 chrX:55009055-55015742 886 nt 0.5745
hsa_ALAS2_0000200 Exon-Exon chrX:55035488-55044098 chrX:55009055-55017665 1066 nt 0.5582
hsa_ALAS2_0000300 Exon-Exon chrX:55035488-55047707 chrX:55009055-55021274 1474 nt 0.5495
hsa_chrX_0336900 Intergenic-Intergenic chrX:55035583-55039960 chrX:55009150-55013527 236 nt 0.5805
hsa_chrX_0337000 Intergenic-Intergenic chrX:55035583-55041266 chrX:55009150-55014833 194 nt 0.5825
hsa_chrX_0337100 Intergenic-Intergenic chrX:55035623-55039960 chrX:55009190-55013527 196 nt 0.5816
hsa_ALAS2_0000400 Exon-Exon chrX:55035671-55040081 chrX:55009238-55013648 269 nt 0.5799
hsa_ALAS2_0000500 Exon-Exon chrX:55035675-55046937 chrX:55009242-55020504 185 nt 0.5730
hsa_chrX_0337200 Intergenic-Intergenic chrX:55035682-55043994 chrX:55009249-55017561 93 nt 0.6022
hsa_ALAS2_0000700 Exon-Exon chrX:55039919-55042175 chrX:55013486-55015742 328 nt 0.5640
Showing 1 to 10 of 25 entries
Forensic Context

A study in humans demonstrated that circALAS2 is used for body fluid identification, specifically for detecting menstrual blood, where detecting circRNAs derived from the same gene as mRNA typing could improve the stability and sensitivity of this identification [Li et al. DOI:10.1093/fsr/owad003]. A study in human body fluid samples demonstrated that the inclusion of circular RNA transcripts of the circALAS2 in mRNA profiling significantly improved detection sensitivity and stability for peripheral blood identification [Zhang et al. DOI:10.1007/s00414-017-1690-7]. The use of primers targeting both linear and circular forms enabled detection down to 0.003 ng of input RNA and provided robust detection in environmentally challenged, degraded, and aged (6-7 years) bloodstains where primers targeting only linear transcripts failed. A subsequent characterization confirmed the circALAS2 as a blood-specific biomarker and found that the inclusion of its circRNAs did not impair specificity [Liu et al. DOI:10.1007/s00414-019-02027-y].