Basic Information

Symbol
circALAS2
RNA Class
circRNA
Alias
5''-Aminolevulinate Synthase 2 ALAS-E 5'-Aminolevulinate Synthase 2 ASB 5-Aminolevulinate Synthase, Erythroid-Specific, Mitochondrial Erythroid-Specific Delta-Aminolevulinate Synthase Aminolevulinate, Delta-, Synthase 2 5-Aminolevulinic Acid Synthase 2 Delta-Aminolevulinate Synthase 2 Delta-ALA Synthase 2 EC 2.3.1.37 ALASE Aminolevulinate, Delta-, Synthase 2 (Sideroblastic/Hypochromic Anemia) Sideroblastic/Hypochromic Anemia Delta-ALA Synthetase SIDBA1 XLDPP XLEPP ANH1 XLSA
Location (GRCh37)
X:55035488-55052396 UCSC Genome Browser
Location (GRCh38)
X:55009055-55025963
UCSC Genome Browser Search in Marker Scope
Host gene
ALAS2
Host category
mRNA
Forensic tag(s)
Tissue/body fluid identification
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_ALAS2_0000600 Exon-Exon chrX:55039919-55044098 chrX:55013486-55017665 777 nt 0.5611
hsa_ALAS2_0000800 Exon-Exon chrX:55039919-55046937 chrX:55013486-55020504 185 nt 0.5730
hsa_ALAS2_0000900 Exon-Exon chrX:55041390-55042175 chrX:55014957-55015742 59 nt 0.6102
hsa_ALAS2_0001000 Exon-Exon chrX:55041399-55044037 chrX:55014966-55017604 169 nt 0.5089
hsa_ALAS2_0001100 Exon-Exon chrX:55042011-55046937 chrX:55015578-55020504 185 nt 0.5730
hsa_ALAS2_0001200 Exon-Exon chrX:55043919-55047707 chrX:55017486-55021274 317 nt 0.5268
hsa_chrX_0337300 Intergenic-Intergenic chrX:55043995-55046898 chrX:55017562-55020465 124 nt 0.5323
hsa_ALAS2_0001300 Exon-Exon chrX:55046799-55052396 chrX:55020366-55025963 135 nt 0.5852
hsa_ALAS2_0001400 Exon-Exon chrX:55047485-55050300 chrX:55021052-55023867 300 nt 0.5233
hsa_ALAS2_0001500 Exon-Exon chrX:55047542-55051196 chrX:55021109-55024763 212 nt 0.4858
Showing 11 to 20 of 25 entries
Forensic Context

A study in humans demonstrated that circALAS2 is used for body fluid identification, specifically for detecting menstrual blood, where detecting circRNAs derived from the same gene as mRNA typing could improve the stability and sensitivity of this identification [Li et al. DOI:10.1093/fsr/owad003]. A study in human body fluid samples demonstrated that the inclusion of circular RNA transcripts of the circALAS2 in mRNA profiling significantly improved detection sensitivity and stability for peripheral blood identification [Zhang et al. DOI:10.1007/s00414-017-1690-7]. The use of primers targeting both linear and circular forms enabled detection down to 0.003 ng of input RNA and provided robust detection in environmentally challenged, degraded, and aged (6-7 years) bloodstains where primers targeting only linear transcripts failed. A subsequent characterization confirmed the circALAS2 as a blood-specific biomarker and found that the inclusion of its circRNAs did not impair specificity [Liu et al. DOI:10.1007/s00414-019-02027-y].