Basic Information

Symbol
circALAS2
RNA Class
circRNA
Alias
5''-Aminolevulinate Synthase 2 ALAS-E 5'-Aminolevulinate Synthase 2 ASB 5-Aminolevulinate Synthase, Erythroid-Specific, Mitochondrial Erythroid-Specific Delta-Aminolevulinate Synthase Aminolevulinate, Delta-, Synthase 2 5-Aminolevulinic Acid Synthase 2 Delta-Aminolevulinate Synthase 2 Delta-ALA Synthase 2 EC 2.3.1.37 ALASE Aminolevulinate, Delta-, Synthase 2 (Sideroblastic/Hypochromic Anemia) Sideroblastic/Hypochromic Anemia Delta-ALA Synthetase SIDBA1 XLDPP XLEPP ANH1 XLSA
Location (GRCh37)
X:55035488-55052396 UCSC Genome Browser
Location (GRCh38)
X:55009055-55025963
UCSC Genome Browser Search in Marker Scope
Host gene
ALAS2
Host category
mRNA
Forensic tag(s)
Tissue/body fluid identification
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_ALAS2_0001600 Exon-Exon chrX:55047547-55052352 chrX:55021114-55025919 362 nt 0.5028
hsa_chrX_0337400 Intergenic-Intergenic chrX:55047641-55050213 chrX:55021208-55023780 91 nt 0.4066
hsa_ALAS2_0001700 Intron-Exon-Intron chrX:55050190-55050885 chrX:55023757-55024452 111 nt 0.5405
hsa_chrX_0337500 Intergenic-Intergenic chrX:55050212-55050448 chrX:55023779-55024015 237 nt 0.4768
hsa_chrX_0337600 Intergenic-Intergenic chrX:55050212-55050976 chrX:55023779-55024543 184 nt 0.4293
Showing 21 to 25 of 25 entries
Forensic Context

A study in humans demonstrated that circALAS2 is used for body fluid identification, specifically for detecting menstrual blood, where detecting circRNAs derived from the same gene as mRNA typing could improve the stability and sensitivity of this identification [Li et al. DOI:10.1093/fsr/owad003]. A study in human body fluid samples demonstrated that the inclusion of circular RNA transcripts of the circALAS2 in mRNA profiling significantly improved detection sensitivity and stability for peripheral blood identification [Zhang et al. DOI:10.1007/s00414-017-1690-7]. The use of primers targeting both linear and circular forms enabled detection down to 0.003 ng of input RNA and provided robust detection in environmentally challenged, degraded, and aged (6-7 years) bloodstains where primers targeting only linear transcripts failed. A subsequent characterization confirmed the circALAS2 as a blood-specific biomarker and found that the inclusion of its circRNAs did not impair specificity [Liu et al. DOI:10.1007/s00414-019-02027-y].