Basic Information
Symbol
circGNB4
RNA Class
circRNA
Alias
G Protein Subunit Beta 4
Guanine Nucleotide-Binding Protein Subunit Beta-4
Transducin Beta Chain 4
Guanine Nucleotide Binding Protein (G Protein), Beta Polypeptide 4
Heterotrimeric Guanine Nucleotide-Binding Protein 2B
G Protein Beta-4 Subunit
CMTD1F
HG2B
Location (GRCh37)
3:179113876-179137293
UCSC Genome Browser
Location (GRCh38)
3:179396088-179419505
Host gene
GNB4
Host category
mRNA
Forensic tag(s)
Sudden cardiac death diagnosis
External database
Transcripts
| ID | Type | Location (GRCh37) | Location (GRCh38) | Length | GC content |
|---|---|---|---|---|---|
| hsa_GNB4_0003200 | Exon-Exon | chr3:179131200-179137293 | chr3:179413412-179419505 | 603 nt | 0.4378 |
| hsa_GNB4_0000600 | Intergenic-Exon | chr3:179113876-179137293 | chr3:179396088-179419505 | 250 nt | 0.3000 |
Forensic Context
A study in human coronary artery samples from a single autopsy case demonstrated that the circGNB4 was validated by qRT-PCR and Sanger sequencing, showing significantly subtler expression in the proximal and mid left anterior descending artery, proximal left circumflex artery, and mid and distal right coronary artery compared to the left main trunk, which had more severe atherosclerosis [Hou et al. DOI:10.1002/jcla.23552].