Basic Information

Symbol
circHECW2
RNA Class
circRNA
Alias
HECT, C2 And WW Domain Containing E3 Ubiquitin Protein Ligase 2 NEDL2 KIAA1301 HECT-Type E3 Ubiquitin Transferase HECW2 NEDD4-Like E3 Ubiquitin-Protein Ligase 2 E3 Ubiquitin-Protein Ligase HECW2 HECT, C2 And WW Domain-Containing Protein 2 NEDD4-Related E3 Ubiquitin Ligase NEDL2 EC 2.3.2.26 EC 6.3.2 NDHSAL
Location (GRCh37)
2:197065695-197457335 UCSC Genome Browser
Location (GRCh38)
2:196200971-196592611
UCSC Genome Browser Search in Marker Scope
Host gene
HECW2
Host category
mRNA
Forensic tag(s)
Drug abuse diagnoses
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_HECW2_0000600 Exon-Exon chr2:197080589-197172809 chr2:196215865-196308085 2173 nt 0.4850
hsa_HECW2_0001400 Exon-Exon chr2:197081732-197172809 chr2:196217008-196308085 2060 nt 0.4850
hsa_HECW2_0001900 Exon-Exon chr2:197084763-197085665 chr2:196220039-196220941 262 nt 0.4618
hsa_HECW2_0002700 Exon-Exon chr2:197090496-197106928 chr2:196225772-196242204 487 nt 0.4333
hsa_HECW2_0002800 Exon-Exon chr2:197090496-197143386 chr2:196225772-196278662 1016 nt 0.4724
hsa_HECW2_0003100 Exon-Exon chr2:197092826-197172809 chr2:196228102-196308085 1483 nt 0.4997
hsa_HECW2_0003200 Exon-Exon chr2:197105173-197106928 chr2:196240449-196242204 235 nt 0.4596
hsa_HECW2_0003300 Exon-Exon chr2:197105173-197138847 chr2:196240449-196274123 629 nt 0.4754
hsa_HECW2_0003400 Exon-Exon chr2:197105173-197143386 chr2:196240449-196278662 764 nt 0.4935
hsa_HECW2_0003500 Exon-Exon chr2:197105173-197172809 chr2:196240449-196308085 1330 nt 0.5128
Showing 1 to 10 of 147 entries
Forensic Context

A study in rodents demonstrated that the circHECW2 is involved in Endothelial-mesenchymal-transition (EndoMT) during methamphetamine abuse, where it inhibits the activity of endogenous miR30D sponge, activating downstream ATG5 and leading to blood-brain barrier damage [Gu et al. DOI:10.1007/s11010-021-04160-y].