Basic Information

Symbol
circHECW2
RNA Class
circRNA
Alias
HECT, C2 And WW Domain Containing E3 Ubiquitin Protein Ligase 2 NEDL2 KIAA1301 HECT-Type E3 Ubiquitin Transferase HECW2 NEDD4-Like E3 Ubiquitin-Protein Ligase 2 E3 Ubiquitin-Protein Ligase HECW2 HECT, C2 And WW Domain-Containing Protein 2 NEDD4-Related E3 Ubiquitin Ligase NEDL2 EC 2.3.2.26 EC 6.3.2 NDHSAL
Location (GRCh37)
2:197065695-197457335 UCSC Genome Browser
Location (GRCh38)
2:196200971-196592611
UCSC Genome Browser Search in Marker Scope
Host gene
HECW2
Host category
mRNA
Forensic tag(s)
Drug abuse diagnoses
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_HECW2_0007300 Intron-Exon-Intron chr2:197135917-197172850 chr2:196271193-196308126 192 nt 0.5781
hsa_HECW2_0006800 Intron-Exon-Intron chr2:197135917-197178813 chr2:196271193-196314089 250 nt 0.3680
hsa_chr2_0394500 Intergenic-Intergenic chr2:197136398-197138061 chr2:196271674-196273337 1664 nt 0.3480
hsa_HECW2_0007500 Intron-Intron chr2:197138094-197138413 chr2:196273370-196273689 320 nt 0.4063
hsa_HECW2_0007600 Exon-Exon chr2:197138745-197143386 chr2:196274021-196278662 238 nt 0.5504
hsa_HECW2_0007700 Exon-Exon chr2:197138745-197157474 chr2:196274021-196292750 109 nt 0.5229
hsa_HECW2_0007800 Exon-Exon chr2:197138745-197172809 chr2:196274021-196308085 250 nt 0.5640
hsa_HECW2_0007900 Intron-Exon chr2:197143054-197143386 chr2:196278330-196278662 333 nt 0.4384
hsa_HECW2_0008000 Intron-Exon-Intron chr2:197143054-197157474 chr2:196278330-196292750 186 nt 0.5161
hsa_HECW2_0008500 Exon-Exon chr2:197143252-197182093 chr2:196278528-196317369 797 nt 0.5533
Showing 91 to 100 of 147 entries
Forensic Context

A study in rodents demonstrated that the circHECW2 is involved in Endothelial-mesenchymal-transition (EndoMT) during methamphetamine abuse, where it inhibits the activity of endogenous miR30D sponge, activating downstream ATG5 and leading to blood-brain barrier damage [Gu et al. DOI:10.1007/s11010-021-04160-y].