Basic Information

Symbol
circHECW2
RNA Class
circRNA
Alias
HECT, C2 And WW Domain Containing E3 Ubiquitin Protein Ligase 2 NEDL2 KIAA1301 HECT-Type E3 Ubiquitin Transferase HECW2 NEDD4-Like E3 Ubiquitin-Protein Ligase 2 E3 Ubiquitin-Protein Ligase HECW2 HECT, C2 And WW Domain-Containing Protein 2 NEDD4-Related E3 Ubiquitin Ligase NEDL2 EC 2.3.2.26 EC 6.3.2 NDHSAL
Location (GRCh37)
2:197065695-197457335 UCSC Genome Browser
Location (GRCh38)
2:196200971-196592611
UCSC Genome Browser Search in Marker Scope
Host gene
HECW2
Host category
mRNA
Forensic tag(s)
Drug abuse diagnoses
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_HECW2_0008600 Exon-Exon chr2:197143252-197189873 chr2:196278528-196325149 414 nt 0.4686
hsa_HECW2_0008400 Exon-Exon chr2:197143252-197298182 chr2:196278528-196433458 250 nt 0.4600
hsa_HECW2_0008700 Exon-Exon chr2:197143257-197157474 chr2:196278533-196292750 130 nt 0.5769
hsa_chr2_0394600 Intergenic-Intergenic chr2:197147033-197147291 chr2:196282309-196282567 259 nt 0.4402
hsa_HECW2_0008800 Intron-Exon-Intron chr2:197153476-197172809 chr2:196288752-196308085 250 nt 0.4320
hsa_HECW2_0008900 Intron-Intron chr2:197154492-197155132 chr2:196289768-196290408 641 nt 0.3947
hsa_HECW2_0009300 Exon-Exon chr2:197157289-197171957 chr2:196292565-196307233 415 nt 0.5181
hsa_HECW2_0009400 Exon-Exon chr2:197157289-197187344 chr2:196292565-196322620 186 nt 0.5161
hsa_HECW2_0009100 Exon-Exon chr2:197157289-197189873 chr2:196292565-196325149 2429 nt 0.5467
hsa_HECW2_0009200 Exon-Exon chr2:197157289-197298182 chr2:196292565-196433458 250 nt 0.4440
Showing 101 to 110 of 147 entries
Forensic Context

A study in rodents demonstrated that the circHECW2 is involved in Endothelial-mesenchymal-transition (EndoMT) during methamphetamine abuse, where it inhibits the activity of endogenous miR30D sponge, activating downstream ATG5 and leading to blood-brain barrier damage [Gu et al. DOI:10.1007/s11010-021-04160-y].