Basic Information

Symbol
circHECW2
RNA Class
circRNA
Alias
HECT, C2 And WW Domain Containing E3 Ubiquitin Protein Ligase 2 NEDL2 KIAA1301 HECT-Type E3 Ubiquitin Transferase HECW2 NEDD4-Like E3 Ubiquitin-Protein Ligase 2 E3 Ubiquitin-Protein Ligase HECW2 HECT, C2 And WW Domain-Containing Protein 2 NEDD4-Related E3 Ubiquitin Ligase NEDL2 EC 2.3.2.26 EC 6.3.2 NDHSAL
Location (GRCh37)
2:197065695-197457335 UCSC Genome Browser
Location (GRCh38)
2:196200971-196592611
UCSC Genome Browser Search in Marker Scope
Host gene
HECW2
Host category
mRNA
Forensic tag(s)
Drug abuse diagnoses
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_HECW2_0009500 Exon-Exon chr2:197157421-197184297 chr2:196292697-196319573 54 nt 0.4259
hsa_HECW2_0010000 Exon-Exon chr2:197171212-197189873 chr2:196306488-196325149 170 nt 0.4882
hsa_HECW2_0009900 Exon-Exon chr2:197171212-197208488 chr2:196306488-196343764 2522 nt 0.5416
hsa_HECW2_0010200 Exon-Exon chr2:197181998-197189873 chr2:196317274-196325149 313 nt 0.4601
hsa_HECW2_0010100 Exon-Exon chr2:197181998-197298182 chr2:196317274-196433458 2469 nt 0.5423
hsa_HECW2_0010300 Exon-Exon chr2:197183276-197184522 chr2:196318552-196319798 1247 nt 0.5742
hsa_HECW2_0010800 Exon-Exon chr2:197187202-197199242 chr2:196322478-196334518 95 nt 0.5053
hsa_HECW2_0010700 Exon-Exon chr2:197187202-197208488 chr2:196322478-196343764 592 nt 0.4696
hsa_HECW2_0010900 Exon-Exon chr2:197194299-197199188 chr2:196329575-196334464 117 nt 0.5299
hsa_HECW2_0011200 Exon-Exon chr2:197194299-197199242 chr2:196329575-196334518 101 nt 0.5050
Showing 111 to 120 of 147 entries
Forensic Context

A study in rodents demonstrated that the circHECW2 is involved in Endothelial-mesenchymal-transition (EndoMT) during methamphetamine abuse, where it inhibits the activity of endogenous miR30D sponge, activating downstream ATG5 and leading to blood-brain barrier damage [Gu et al. DOI:10.1007/s11010-021-04160-y].