Basic Information

Symbol
circHECW2
RNA Class
circRNA
Alias
HECT, C2 And WW Domain Containing E3 Ubiquitin Protein Ligase 2 NEDL2 KIAA1301 HECT-Type E3 Ubiquitin Transferase HECW2 NEDD4-Like E3 Ubiquitin-Protein Ligase 2 E3 Ubiquitin-Protein Ligase HECW2 HECT, C2 And WW Domain-Containing Protein 2 NEDD4-Related E3 Ubiquitin Ligase NEDL2 EC 2.3.2.26 EC 6.3.2 NDHSAL
Location (GRCh37)
2:197065695-197457335 UCSC Genome Browser
Location (GRCh38)
2:196200971-196592611
UCSC Genome Browser Search in Marker Scope
Host gene
HECW2
Host category
mRNA
Forensic tag(s)
Drug abuse diagnoses
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_HECW2_0011000 Exon-Exon chr2:197194299-197208488 chr2:196329575-196343764 279 nt 0.4803
hsa_HECW2_0011100 Exon-Exon chr2:197194299-197298182 chr2:196329575-196433458 606 nt 0.5215
hsa_HECW2_0011300 Exon-Exon chr2:197199148-197298182 chr2:196334424-196433458 95 nt 0.5053
hsa_HECW2_0011400 Exon-Exon chr2:197208381-197298182 chr2:196343657-196433458 108 nt 0.4537
hsa_chr2_0394700 Intergenic-Intergenic chr2:197209500-197209693 chr2:196344776-196344969 194 nt 0.4021
hsa_chr2_0394800 Intergenic-Intergenic chr2:197217737-197217876 chr2:196353013-196353152 140 nt 0.5500
hsa_chr2_0394900 Intergenic-Intergenic chr2:197224124-197224460 chr2:196359400-196359736 337 nt 0.3294
hsa_HECW2_0011500 Intron-Exon-Intron chr2:197226536-197298182 chr2:196361812-196433458 250 nt 0.3840
hsa_HECW2_0011600 Intron-Exon-Intron chr2:197226536-197358099 chr2:196361812-196493375 250 nt 0.3760
hsa_HECW2_0011700 Intron-Exon-Intron chr2:197240663-197298182 chr2:196375939-196433458 250 nt 0.4040
Showing 121 to 130 of 147 entries
Forensic Context

A study in rodents demonstrated that the circHECW2 is involved in Endothelial-mesenchymal-transition (EndoMT) during methamphetamine abuse, where it inhibits the activity of endogenous miR30D sponge, activating downstream ATG5 and leading to blood-brain barrier damage [Gu et al. DOI:10.1007/s11010-021-04160-y].