Basic Information

Symbol
circHECW2
RNA Class
circRNA
Alias
HECT, C2 And WW Domain Containing E3 Ubiquitin Protein Ligase 2 NEDL2 KIAA1301 HECT-Type E3 Ubiquitin Transferase HECW2 NEDD4-Like E3 Ubiquitin-Protein Ligase 2 E3 Ubiquitin-Protein Ligase HECW2 HECT, C2 And WW Domain-Containing Protein 2 NEDD4-Related E3 Ubiquitin Ligase NEDL2 EC 2.3.2.26 EC 6.3.2 NDHSAL
Location (GRCh37)
2:197065695-197457335 UCSC Genome Browser
Location (GRCh38)
2:196200971-196592611
UCSC Genome Browser Search in Marker Scope
Host gene
HECW2
Host category
mRNA
Forensic tag(s)
Drug abuse diagnoses
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_HECW2_0004100 Exon-Exon chr2:197106808-197118753 chr2:196242084-196254029 231 nt 0.5195
hsa_HECW2_0004700 Exon-Exon chr2:197118644-197143386 chr2:196253920-196278662 529 nt 0.5085
hsa_HECW2_0004800 Exon-Exon chr2:197118644-197172809 chr2:196253920-196308085 1095 nt 0.5242
hsa_HECW2_0005600 Exon-Exon chr2:197122547-197136013 chr2:196257823-196271289 181 nt 0.4420
hsa_HECW2_0005700 Exon-Exon chr2:197122547-197143386 chr2:196257823-196278662 419 nt 0.5036
hsa_HECW2_0005800 Exon-Exon chr2:197122547-197172809 chr2:196257823-196308085 985 nt 0.5239
hsa_HECW2_0006100 Exon-Exon chr2:197135917-197136013 chr2:196271193-196271289 97 nt 0.4021
hsa_HECW2_0006200 Exon-Exon chr2:197135917-197143386 chr2:196271193-196278662 335 nt 0.5075
hsa_HECW2_0006300 Exon-Exon chr2:197135917-197157474 chr2:196271193-196292750 521 nt 0.5106
hsa_HECW2_0006400 Exon-Exon chr2:197135917-197172809 chr2:196271193-196308085 901 nt 0.5272
Showing 11 to 20 of 147 entries
Forensic Context

A study in rodents demonstrated that the circHECW2 is involved in Endothelial-mesenchymal-transition (EndoMT) during methamphetamine abuse, where it inhibits the activity of endogenous miR30D sponge, activating downstream ATG5 and leading to blood-brain barrier damage [Gu et al. DOI:10.1007/s11010-021-04160-y].