Basic Information

Symbol
circHECW2
RNA Class
circRNA
Alias
HECT, C2 And WW Domain Containing E3 Ubiquitin Protein Ligase 2 NEDL2 KIAA1301 HECT-Type E3 Ubiquitin Transferase HECW2 NEDD4-Like E3 Ubiquitin-Protein Ligase 2 E3 Ubiquitin-Protein Ligase HECW2 HECT, C2 And WW Domain-Containing Protein 2 NEDD4-Related E3 Ubiquitin Ligase NEDL2 EC 2.3.2.26 EC 6.3.2 NDHSAL
Location (GRCh37)
2:197065695-197457335 UCSC Genome Browser
Location (GRCh38)
2:196200971-196592611
UCSC Genome Browser Search in Marker Scope
Host gene
HECW2
Host category
mRNA
Forensic tag(s)
Drug abuse diagnoses
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_HECW2_0006500 Exon-Exon chr2:197135917-197189873 chr2:196271193-196325149 2764 nt 0.5420
hsa_HECW2_0006600 Exon-Exon chr2:197135917-197208488 chr2:196271193-196343764 250 nt 0.3440
hsa_HECW2_0007400 Exon-Exon chr2:197135917-197226946 chr2:196271193-196362222 250 nt 0.3600
hsa_HECW2_0006700 Exon-Exon chr2:197135917-197298182 chr2:196271193-196433458 250 nt 0.3920
hsa_HECW2_0008100 Exon-Exon chr2:197143252-197143386 chr2:196278528-196278662 135 nt 0.5778
hsa_HECW2_0008200 Exon-Exon chr2:197143252-197157474 chr2:196278528-196292750 321 nt 0.5421
hsa_HECW2_0008300 Exon-Exon chr2:197143252-197172809 chr2:196278528-196308085 701 nt 0.5464
hsa_HECW2_0009000 Exon-Exon chr2:197157289-197172809 chr2:196292565-196308085 566 nt 0.5389
hsa_HECW2_0009600 Exon-Exon chr2:197171212-197171336 chr2:196306488-196306612 125 nt 0.5360
hsa_HECW2_0009700 Exon-Exon chr2:197171212-197172809 chr2:196306488-196308085 380 nt 0.5500
Showing 21 to 30 of 147 entries
Forensic Context

A study in rodents demonstrated that the circHECW2 is involved in Endothelial-mesenchymal-transition (EndoMT) during methamphetamine abuse, where it inhibits the activity of endogenous miR30D sponge, activating downstream ATG5 and leading to blood-brain barrier damage [Gu et al. DOI:10.1007/s11010-021-04160-y].