Basic Information

Symbol
circHECW2
RNA Class
circRNA
Alias
HECT, C2 And WW Domain Containing E3 Ubiquitin Protein Ligase 2 NEDL2 KIAA1301 HECT-Type E3 Ubiquitin Transferase HECW2 NEDD4-Like E3 Ubiquitin-Protein Ligase 2 E3 Ubiquitin-Protein Ligase HECW2 HECT, C2 And WW Domain-Containing Protein 2 NEDD4-Related E3 Ubiquitin Ligase NEDL2 EC 2.3.2.26 EC 6.3.2 NDHSAL
Location (GRCh37)
2:197065695-197457335 UCSC Genome Browser
Location (GRCh38)
2:196200971-196592611
UCSC Genome Browser Search in Marker Scope
Host gene
HECW2
Host category
mRNA
Forensic tag(s)
Drug abuse diagnoses
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_HECW2_0009800 Exon-Exon chr2:197171212-197182093 chr2:196306488-196317369 476 nt 0.5609
hsa_HECW2_0010400 Exon-Exon chr2:197185063-197189873 chr2:196320339-196325149 414 nt 0.4686
hsa_HECW2_0010500 Exon-Exon chr2:197185063-197298182 chr2:196320339-196433458 1020 nt 0.5000
hsa_HECW2_0010600 Exon-Exon chr2:197185063-197457335 chr2:196320339-196592611 1168 nt 0.5043
hsa_HECW2_0012200 Exon-Exon chr2:197297856-197298182 chr2:196433132-196433458 327 nt 0.5566
hsa_HECW2_0012400 Exon-Exon chr2:197297856-197358099 chr2:196433132-196493375 250 nt 0.4080
hsa_HECW2_0012500 Intron-Intron chr2:197329727-197329840 chr2:196465003-196465116 114 nt 0.4649
hsa_AC020571.3_0000100 Intergenic-Exon-Intergenic chr2:197105202-197135934 chr2:196240478-196271210 418 nt 0.4809
hsa_AC020571.3_0000200 Intergenic-Exon-Intergenic chr2:197124072-197129937 chr2:196259348-196265213 250 nt 0.3160
hsa_RN7SL820P_0000100 Intergenic-Exon-Intergenic chr2:197143285-197157406 chr2:196278561-196292682 220 nt 0.5455
Showing 31 to 40 of 147 entries
Forensic Context

A study in rodents demonstrated that the circHECW2 is involved in Endothelial-mesenchymal-transition (EndoMT) during methamphetamine abuse, where it inhibits the activity of endogenous miR30D sponge, activating downstream ATG5 and leading to blood-brain barrier damage [Gu et al. DOI:10.1007/s11010-021-04160-y].