Basic Information

Symbol
circHECW2
RNA Class
circRNA
Alias
HECT, C2 And WW Domain Containing E3 Ubiquitin Protein Ligase 2 NEDL2 KIAA1301 HECT-Type E3 Ubiquitin Transferase HECW2 NEDD4-Like E3 Ubiquitin-Protein Ligase 2 E3 Ubiquitin-Protein Ligase HECW2 HECT, C2 And WW Domain-Containing Protein 2 NEDD4-Related E3 Ubiquitin Ligase NEDL2 EC 2.3.2.26 EC 6.3.2 NDHSAL
Location (GRCh37)
2:197065695-197457335 UCSC Genome Browser
Location (GRCh38)
2:196200971-196592611
UCSC Genome Browser Search in Marker Scope
Host gene
HECW2
Host category
mRNA
Forensic tag(s)
Drug abuse diagnoses
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_HECW2_0000200 Exon-Exon chr2:197065695-197084877 chr2:196200971-196220153 121 nt 0.4628
hsa_HECW2_0000300 Exon-Exon chr2:197065695-197085665 chr2:196200971-196220941 147 nt 0.4694
hsa_HECW2_0000100 Exon-Exon chr2:197065695-197106928 chr2:196200971-196242204 1496 nt 0.4459
hsa_HECW2_0000400 Exon-Exon chr2:197065815-197085665 chr2:196201091-196220941 298 nt 0.4497
hsa_HECW2_0000500 Exon-Exon chr2:197065815-197106928 chr2:196201091-196242204 127 nt 0.5039
hsa_HECW2_0000800 Exon-Exon chr2:197080589-197084877 chr2:196215865-196220153 228 nt 0.4693
hsa_HECW2_0000900 Exon-Exon chr2:197080589-197087064 chr2:196215865-196222340 329 nt 0.4498
hsa_HECW2_0001000 Exon-Exon chr2:197080589-197092978 chr2:196215865-196228254 467 nt 0.4304
hsa_HECW2_0001100 Exon-Exon chr2:197080589-197106928 chr2:196215865-196242204 127 nt 0.5197
hsa_HECW2_0001200 Exon-Exon chr2:197080589-197138847 chr2:196215865-196274123 113 nt 0.4867
Showing 41 to 50 of 147 entries
Forensic Context

A study in rodents demonstrated that the circHECW2 is involved in Endothelial-mesenchymal-transition (EndoMT) during methamphetamine abuse, where it inhibits the activity of endogenous miR30D sponge, activating downstream ATG5 and leading to blood-brain barrier damage [Gu et al. DOI:10.1007/s11010-021-04160-y].