Basic Information

Symbol
circHECW2
RNA Class
circRNA
Alias
HECT, C2 And WW Domain Containing E3 Ubiquitin Protein Ligase 2 NEDL2 KIAA1301 HECT-Type E3 Ubiquitin Transferase HECW2 NEDD4-Like E3 Ubiquitin-Protein Ligase 2 E3 Ubiquitin-Protein Ligase HECW2 HECT, C2 And WW Domain-Containing Protein 2 NEDD4-Related E3 Ubiquitin Ligase NEDL2 EC 2.3.2.26 EC 6.3.2 NDHSAL
Location (GRCh37)
2:197065695-197457335 UCSC Genome Browser
Location (GRCh38)
2:196200971-196592611
UCSC Genome Browser Search in Marker Scope
Host gene
HECW2
Host category
mRNA
Forensic tag(s)
Drug abuse diagnoses
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_HECW2_0001300 Exon-Exon chr2:197080589-197143386 chr2:196215865-196278662 119 nt 0.4874
hsa_HECW2_0000700 Exon-Exon chr2:197080589-197157474 chr2:196215865-196292750 1793 nt 0.4713
hsa_HECW2_0001500 Exon-Exon chr2:197081732-197106928 chr2:196217008-196242204 965 nt 0.4404
hsa_HECW2_0001600 Exon-Exon chr2:197081732-197182093 chr2:196217008-196317369 96 nt 0.6042
hsa_HECW2_0001700 Intron-Exon-Intron chr2:197084508-197085665 chr2:196219784-196220941 517 nt 0.4352
hsa_HECW2_0001800 Intron-Exon-Intron chr2:197084524-197085665 chr2:196219800-196220941 501 nt 0.4331
hsa_HECW2_0002000 Exon-Exon chr2:197084763-197092978 chr2:196220039-196228254 153 nt 0.3856
hsa_HECW2_0002100 Exon-Exon chr2:197084763-197106928 chr2:196220039-196242204 127 nt 0.5197
hsa_HECW2_0002200 Exon-Exon chr2:197084763-197143386 chr2:196220039-196278662 135 nt 0.5778
hsa_HECW2_0002300 Exon-Exon chr2:197084763-197172809 chr2:196220039-196308085 151 nt 0.5960
Showing 51 to 60 of 147 entries
Forensic Context

A study in rodents demonstrated that the circHECW2 is involved in Endothelial-mesenchymal-transition (EndoMT) during methamphetamine abuse, where it inhibits the activity of endogenous miR30D sponge, activating downstream ATG5 and leading to blood-brain barrier damage [Gu et al. DOI:10.1007/s11010-021-04160-y].