Basic Information

Symbol
circHECW2
RNA Class
circRNA
Alias
HECT, C2 And WW Domain Containing E3 Ubiquitin Protein Ligase 2 NEDL2 KIAA1301 HECT-Type E3 Ubiquitin Transferase HECW2 NEDD4-Like E3 Ubiquitin-Protein Ligase 2 E3 Ubiquitin-Protein Ligase HECW2 HECT, C2 And WW Domain-Containing Protein 2 NEDD4-Related E3 Ubiquitin Ligase NEDL2 EC 2.3.2.26 EC 6.3.2 NDHSAL
Location (GRCh37)
2:197065695-197457335 UCSC Genome Browser
Location (GRCh38)
2:196200971-196592611
UCSC Genome Browser Search in Marker Scope
Host gene
HECW2
Host category
mRNA
Forensic tag(s)
Drug abuse diagnoses
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_HECW2_0002500 Exon-Exon chr2:197086935-197092930 chr2:196222211-196228206 130 nt 0.4462
hsa_HECW2_0002400 Exon-Exon chr2:197086935-197092978 chr2:196222211-196228254 382 nt 0.4215
hsa_HECW2_0002600 Exon-Exon chr2:197086935-197143386 chr2:196222211-196278662 387 nt 0.4677
hsa_HECW2_0002900 Exon-Exon chr2:197090496-197092978 chr2:196225772-196228254 252 nt 0.4087
hsa_HECW2_0003000 Exon-Exon chr2:197090496-197172809 chr2:196225772-196308085 337 nt 0.5519
hsa_HECW2_0003600 Exon-Exon chr2:197105173-197118753 chr2:196240449-196254029 345 nt 0.4812
hsa_HECW2_0003700 Exon-Exon chr2:197105173-197122630 chr2:196240449-196257906 429 nt 0.4825
hsa_HECW2_0003800 Exon-Exon chr2:197105173-197136013 chr2:196240449-196271289 103 nt 0.4175
hsa_HECW2_0003900 Exon-Exon chr2:197105173-197157474 chr2:196240449-196292750 345 nt 0.4812
hsa_HECW2_0004000 Exon-Exon chr2:197105173-197189873 chr2:196240449-196325149 114 nt 0.4035
Showing 61 to 70 of 147 entries
Forensic Context

A study in rodents demonstrated that the circHECW2 is involved in Endothelial-mesenchymal-transition (EndoMT) during methamphetamine abuse, where it inhibits the activity of endogenous miR30D sponge, activating downstream ATG5 and leading to blood-brain barrier damage [Gu et al. DOI:10.1007/s11010-021-04160-y].