Basic Information

Symbol
circHECW2
RNA Class
circRNA
Alias
HECT, C2 And WW Domain Containing E3 Ubiquitin Protein Ligase 2 NEDL2 KIAA1301 HECT-Type E3 Ubiquitin Transferase HECW2 NEDD4-Like E3 Ubiquitin-Protein Ligase 2 E3 Ubiquitin-Protein Ligase HECW2 HECT, C2 And WW Domain-Containing Protein 2 NEDD4-Related E3 Ubiquitin Ligase NEDL2 EC 2.3.2.26 EC 6.3.2 NDHSAL
Location (GRCh37)
2:197065695-197457335 UCSC Genome Browser
Location (GRCh38)
2:196200971-196592611
UCSC Genome Browser Search in Marker Scope
Host gene
HECW2
Host category
mRNA
Forensic tag(s)
Drug abuse diagnoses
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_HECW2_0004300 Exon-Exon chr2:197106808-197143386 chr2:196242084-196278662 135 nt 0.5778
hsa_HECW2_0004200 Exon-Exon chr2:197106808-197171957 chr2:196242084-196307233 1065 nt 0.5127
hsa_HECW2_0004400 Exon-Exon chr2:197106808-197172809 chr2:196242084-196308085 127 nt 0.5197
hsa_chr2_0394300 Intergenic-Intergenic chr2:197111399-197111755 chr2:196246675-196247031 357 nt 0.3473
hsa_HECW2_0004500 Intron-Exon-Intron chr2:197114831-197172809 chr2:196250107-196308085 250 nt 0.4440
hsa_chr2_0394400 Intergenic-Intergenic chr2:197116341-197117144 chr2:196251617-196252420 804 nt 0.4303
hsa_HECW2_0004600 Intron-Exon-Intron chr2:197117298-197118753 chr2:196252574-196254029 1456 nt 0.3922
hsa_HECW2_0005100 Exon-Exon chr2:197118644-197122630 chr2:196253920-196257906 194 nt 0.5103
hsa_HECW2_0005200 Exon-Exon chr2:197118644-197138847 chr2:196253920-196274123 394 nt 0.4848
hsa_HECW2_0005300 Exon-Exon chr2:197118644-197157474 chr2:196253920-196292750 207 nt 0.4686
Showing 71 to 80 of 147 entries
Forensic Context

A study in rodents demonstrated that the circHECW2 is involved in Endothelial-mesenchymal-transition (EndoMT) during methamphetamine abuse, where it inhibits the activity of endogenous miR30D sponge, activating downstream ATG5 and leading to blood-brain barrier damage [Gu et al. DOI:10.1007/s11010-021-04160-y].